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Articles by R Prasad
Total Records ( 3 ) for R Prasad
  R Prasad , B. K Das , R Pengoria , O. P Mishra , J Shukla and T. B. Singh

This study was undertaken to observe the changes in coagulation and platelet profile, and findings were correlated with their outcome. Forty consecutive children with severe falciparum malaria were studied for their coagulation status, i.e. prothrombin time (PT), activated thromboplastin time (APTT), thrombin time (TT) and anti-thrombin-III (AT-III), platelet profile (platelet count, platelet aggregation with adenine diphosphate (ADP) and ADR and PF3 availability). Derangements in the coagulation profile in the form of increased PT, APTT and/or TT were seen in 47.5, 35 and 62.5% cases, respectively, but bleeding was seen in only six cases. Thrombocytopenia was found in 34 patients. Platelet aggregation with ADP and ADR revealed hypoaggregation in 95.3 and 97.5% cases, respectively, and were statistically significant. Platelet factor-3 availability was also significantly prolonged. Patients with prolonged PT, PF-3 and hypoaggregation with adrenaline had 1.4, 1.7 and 1.45 times higher risk of mortality.

  U. K Singh , R Prasad , B. P Jaiswal , P. K Singh and C. P. Thakur

A randomized study was carried out to compare the efficacy and adverse reactions of daily vs. alternate day regimens of amphotericin B in children with visceral leishmaniasis (VL). Six hundred and five children of VL below 14 years of age were randomized into two groups; Group A (302), who received amphotericin B at a dose of 1 mg kg–1 day–1 for 15 days and Group B (303); same doses but on alternate days. All patients in both groups were cured, who had completed course of amphotericin B therapy. None had relapsed at 1 and 6 months of follow-up. Adverse reactions in both groups were non-significant. The duration of stay and cost of therapy was significantly lower in Group A children who left the hospital against medical advice, which was also significantly more in Group B. Thus, daily regimen of amphotericin B is equally effective, well tolerated, not more toxic and cost-effective than alternate day regimen, which is currently practiced.

  P Rawal , B. R Thapa , R Prasad , K. K Prasad , C. K Nain and K. Singh

Background and objectives: This study was conducted to evaluate plasma levels of zinc in children with celiac disease, to correlate plasma zinc levels among the celiacs with short stature and diarrhea and to compare plasma zinc levels in deficient patients on gluten-free diet (GFD) with or without 4 weeks of zinc supplementation.

Methods: A total of 134 patients underwent plasma zinc estimation at baseline and after a four week period. Zinc-deficient patients were randomly assigned to two groups. Group G (n = 48) received GFD without zinc supplementation, Group G + Z (n = 48) received GFD with zinc supplementation for 4 weeks.

Results: The rise in plasma Zinc levels was significant in each group regardless of zinc supplementation but similar when compared in the two groups after 4 weeks. Mean zinc levels at baseline and increase in zinc levels were statistically similar at 4 weeks in patients with diarrhea and short stature.

Conclusions: Zinc levels rise with GFD irrespective of zinc supplementation.

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