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Articles by Qing Wang
Total Records ( 4 ) for Qing Wang
  Zi-Liang Wang , Xiao-Peng Xu , Bai-Liang He , Shao-Ping Weng , Jia Xiao , Li Wang , Ting Lin , Xi Liu , Qing Wang , Xiao-Qiang Yu and Jian-Guo He
  Infectious spleen and kidney necrosis virus (ISKNV) causes a pandemic and serious disease in fish. Infection by ISKNV causes epidermal lesions, in which petechial hemorrhages and abdominal edema are prominent features. ISKNV ORF48R contains a domain similar to that of the platelet-derived growth factor and vascular endothelial growth factor (VEGF) families of proteins. ISKNV ORF48R showed higher similarity to the VEGFs encoded by Megalocytivirus and Parapoxvirus than to those encoded in fish and mammals. We used zebrafish as a model and constructed a recombinant plasmid containing the DNA sequence of ISKNV ORF48R to study ISKNV infection. The plasmid was microinjected into zebrafish embryos at the one-cell stage. Overexpression of the ISKNV ORF48R gene results in pericardial edema and dilation at the tail region of zebrafish embryos, suggesting that ISKNV ORF48R induces vascular permeability. ISKNV ORF48R is also able to stimulate a striking expression of flk1 in the zebrafish dorsal aorta and the axial vein. Furthermore, ISKNV ORF48R, while cooperating with zebrafish VEGF121, can stimulate more striking expression of flk1 than can either ISKNV ORF48R or zebrafish VEGF121 alone. However, decreased expression of FLK-1 by gene knockdown results in the disappearance of pericardial edema and dilation at the tail region of zebrafish embryos induced by overexpression of ISKNV ORF48R in the early stages of embryonic development.
  Qing Wang , Chang-an Yang , Helou Xie , Xingzhu Wang and Hailiang Zhang
  Three sets of novel side-chain liquid-crystalline polymers, poly[3-(4'-methoxy-4-oxy hexyloxy azobenzene) benzyl methacrylate] (PHABM), poly[3, 5-di(4'-methoxy-4-oxy hexyloxy azobenzene) benzyl methacrylate] (PDHABM) and poly[3, 4, 5-tri(4'-methoxy-4-oxy hexyloxy azobenzene) benzyl methacrylate] (PTHABM), with different mesogenic densities were successfully designed and synthesised. The chemical structures of all the monomers were confirmed by 1H nuclear magnetic resonance (NMR), and 13C NMR spectroscopy and elemental analysis, and the characterisation of the polymers was performed by 1H NMR spectroscopy and gel permeation chromatography. Their phase structures and transitions were investigated using differential scanning calorimetry, polarising optical microscopy and single-angle X-ray scattering in order to study the effect of mesogenic density on liquid-crystalline behaviour. Each of the PHABMs exhibited only a glass transition and a smectic phase during the heating and cooling process, while PDHABMs and PTHABMs showed a glass transition and broader temperature range liquid-crystalline behaviour, including both nematic and smectic phases. In addition, the clearing temperatures of the three types of polymers were found to be in the order: PTHABM > PDHABM > PHABM, and the liquid crystal temperature range had the same order.
  Chang-An Yang , Qing Wang , HeLou Xie , GuanQun Zhong and HaiLiang Zhang
  Three sets of novel side-chain liquid crystalline polymers with monosubstituted azobenzene moieties in the side-chain have been studied. These are poly(p-(4'-methoxy-4-oxyhexyloxy azobenzene) benzyl methacrylate) (PPHABM), poly(m-(4'-methoxy-4-oxyhexyloxy azobenzene) benzyl methacrylate) (PMHABM) and poly(o-(4'-methoxy-4-oxyhexyloxy azobenzene) benzyl methacrylate) (POHABM). The chemical structure of the monomers was confirmed by 1H NMR, 13C NMR spectroscopy and elemental analysis. The structural characterisation of the polymers was performed by 1H NMR spectroscopy and gel permeation chromatography, and their phase behaviour and liquid crystalline properties were studied using differential scanning calorimetry, polarised optical microscopy and wide-angle X-ray diffraction. The results show that the transitional behaviour of side-chain liquid crystalline polymers containing monosubstituted azobenzene moieties depends strongly on the position of the substituent on the azobenzene moiety; for example, the ortho-monosubstituted polymers do not form liquid crystalline phases, but all the para- and meta-monosubstituted polymers exhibit a smectic A phase. Furthermore, the glass transition temperature (Tg) of the polymers decreases in the order, para > meta > ortho. For the PPHABM and PMHABM polymers the isotropic temperature (Ti) and liquid crystalline range (ΔT, from Tg to Ti) are found to be in the order, para > meta, although it is surprising that the associated enthalpy changes in these polymers is the opposite order, meta > para.
  Nicolas Picard , Dominique Eladari , Soumaya El Moghrabi , Carole Planes , Soline Bourgeois , Pascal Houillier , Qing Wang , Michel Burnier , Georges Deschenes , Mark A. Knepper , Pierre Meneton and Regine Chambrey
  An inverse relationship exists between urinary tissue kallikrein (TK) excretion and blood pressure in humans and rodents. In the kidney TK is synthesized in large amounts in the connecting tubule and is mainly released into the urinary fluid where its function remains unknown. In the present study mice with no functional gene coding for TK (TK/) were used to test whether the enzyme regulates apically expressed sodium transporters. Semiquantitative immunoblotting of the renal cortex revealed an absence of the 70-kDa form of γ-ENaC in TK/ mice. Urinary Na+ excretion after amiloride injection was blunted in TK/ mice, consistent with reduced renal ENaC activity. Amiloride-sensitive transepithelial potential difference in the colon, where TK is also expressed, was decreased in TK/ mice, whereas amiloride-sensitive alveolar fluid clearance in the lung, where TK is not expressed, was unchanged. In mice lacking the B2 receptor for kinins, the abundance of the 70-kDa form of γ-ENaC was increased, indicating that its absence in TK/ mice is not kinin-mediated. Incubation of membrane proteins from renal cortex of TK/ mice with TK resulted in the appearance of the 70-kDa band of the γ-ENaC, indicating that TK was able to promote γ-ENaC cleavage in vitro. Finally, in mouse cortical collecting ducts isolated and microperfused in vitro, the addition of TK in the luminal fluid increased significantly intracellular Na+ concentration, consistent with an activation of the luminal entry of the cation. The results demonstrate that TK, like several other proteases, can activate ENaC in the kidney and the colon.
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