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Articles by Qin Li
Total Records ( 6 ) for Qin Li
  Qin Li and Yunjun Yan
  A new technique of biodiesel production from Sapium sebiferum oil catalyzed by immobilized lipase from Pseudomonas cepacia G63 prepared in our laboratory was investigated in this study. The independent factors were studied and the significant factors to the yield of biodeisel were confirmed, and the Box–Behnken design was employed to evaluate the effects of those significant factors on yield in preparation of biodiesel. Results indicated the optimal condition for biodiesel preparation were: 4:1 methano/oil molar ratio, 2.7% (w/w) lipase, temperature 41 °C, and the subsequent verification experiment got a result of (96.22%) kept coincided with the predicted biodiesel yield (97.07%) under the optimal conditions, and R2 = 98.19% shown the model was considered to be accurate and available for predicting the yield of biodiesel. There was no loss nearly in the immobilized lipase activity after being repeatedly used for 20 cycles at the optimal reaction condition.
  Feng-yang Chen , Tian-li Teng , Qin Li , Shi-fang Xu , Qun Chen , Xiao-yu Li and Yi-ping Ye
  Background and Objective: The prevalence of Ulcerative Colitis (UC) in most countries has increased and it is necessary to develop new therapeutic options for UC. Siegesbeckia pubescens is a traditional Chinese medicine widely used for the treatment of inflammatory and autoimmune diseases in clinic. The purpose of this study is to evaluate its therapeutic effect against UC. Materials and Methods: Experimental UC in rats was induced by iodoacetamide (IA) through instilling into the lumen of the colon. The aqueous extract of S. pubescens (SPA) was orally administered 3 days before IA instillation and continued upto 4 days. Throughout the experiment, rats were monitored for body weight loss, stool consistency and fecal occult blood which were quantified as Disease Activity Index (DAI). At the end of the experiment, rats were sacrificed and colonic length, weight, macroscopic and histopathological damage were examined. Furthermore, the mRNA expression levels of pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) were analyzed in the colonic tissues by real-time PCR. The data were examined for their statistical significance of difference with ANOVA and the standard’s t-test. Results: The results showed that SPA significantly ameliorated typical symptoms of IA-induced rat colitis including weight loss, mucus stool and bloody diarrhea. Moreover, macroscopic and histopathologic scoring showed that SPA suppressed IA-induced colonic edema, hyperemia, necrotic destruction of epithelium and inflammatory cellular infiltration. In addition, SPA inhibited IA-induced pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) mRNA expression in colon. Conclusion: These evidences indicated that SPA has therapeutic effects against IA-induced colitis in rats which suggested the potential of S. pubescens as an agent for use in the treatment of UC for the first time.
  Jinmiao Lu , Qin Li , Xiaoxia Li and Zhiping Li
  Background and Objective: Ceftriaxone is a frequently used antibiotic in children. This paper is to raise awareness of the challenges in managing ceftriaxone-induced hemolytic anemia and requesting more successful and useful predicting tools in its detection and prevention in pharmacogenomics field. Methodology: An adversary case report of a 5 years old boy who died from ceftriaxone-induced hemolytic anemia within 12 h in children’s hospital though all resuscitation attempt made. Results: Soon after intravenously ceftriaxone, the patient developed acute reaction to ceftriaxone presented with cold and pallor skin with shallow breath etc. Therefore, ceftriaxone infusion was stopped immediately and the patient was moved to emergency room (ER) for resuscitation from hematology outpatient clinic. Until his heart rhythm returned to normal and stabilized, he was then transferred to Pediatric Intensive Care Unit (PICU). Further, the patient developed bradycardia, reduced blood pressure, unconsciousness, under-responsiveness and oliguria. Additionally, his urine was turned from pale yellow to dark red. Urinalysis determined occult blood and trace protein existence. The hemoglobin level was 9.2 g L–1. Coomb’s test came back strong positive accompany with positive anti-C3d antibody. Hemolytic crisis was suspected. Unsuccessfully, the patient died from hemolytic shock, although all emergent resuscitation attempts were made. Conclusion: Ceftriaxone induced autoimmune hemolytic is extremely rare but could be severe as life-threatening condition stressed in pediatric. Its treatment is clinical challenging with poor outcome. Therefore, prevention is the key compared to treatment.
  Nawras Hamdan , Rashad Alkasir , Ying-Sai Fan , Qin Li , Huan-Huan Li , Shi-Qi Dong , Kai Fan and Zhong-Jie Liu
  Background and Objective: Baicalein is an effective anti-cancer treatment of several cancer types. Although numerous studies on baicalein efficacy have been published, the specific mechanism of its cancer inhibition remains unclear. Present study was aimed to provide detailed molecular targets and signaling pathways that baicalein regulated, which may contribute to better application of baicalein in osteosarcoma cure. Materials and Methods: In this study, after treatment of human osteosarcoma cells lines SaOS-2 with baicalein, the CCK-8 assay was used to determine cell viability. The RNA sequencing was used to examine whole transcriptome variation and analyzed by Gene ontology, Kyoto Encyclopedia of Genes and Genomes and Hierarchical clustering. Apoptosis was studied by flow cytometry. Wound healing, adhesion, ATP assays followed by evaluating the expression of mRNA and protein of COL1A2, COL6A1, LAMA5, ITGA4, ITGB1, MMP2 and BINP3 via quantitative real-time PCR and western blot respectively. Results: The dose of 25 μg mL1 of baicalein inhibited the cells proliferation in time dependent manner. The extracellular matrix receptors including the integrin (ITGA4 and ITGB1), collagen (COL1A2, COL6A1) and laminin (LAMA5) were significantly repressed in challenged cells groups at messenger RNA and protein expression level. Furthermore, the migration, adhesion as well as ATP level were statically reduced, whereas cell apoptosis was stimulated. Conclusion: The result supported that baicalein promotes the SaOS-2 apoptosis process. This study suggests that baicalein may be used alone or with other anti-cancer treatments to reverse ECM receptor-associated malignant phenotype of human cancers.
  Irakoze Pierre Claver , Haihua Zhang , Qin Li , Zhou Kexue and Huiming Zhou
  Ultrasonic technology was applied for polysaccharides extraction from the Chinese malted sorghum and Response Surface Methodology (RSM) was used to optimize the effects of processing parameters on polysaccharides yields. Three independent variables were ultrasonic power (X1), extraction time (X2) and ratio of water to raw material (X3), respectively. The statistical analysis indicated that three variables and the quadratic of X1 and X2 had significant effects on the yields and followed by the significant interaction effects between the variables of X2 and X3 (p<0.05). A mathematical model with high determination coefficient was gained and could be employed to optimize polysaccharides extraction. The optimal extraction conditions of polysaccharides were determined as follows: Ultrasonic power 600 W, extraction time 4 min, ratio of water to raw material 30 ml/g. Under these conditions, the experimental yield of polysaccharides was 17.08±0.33%, which was agreed closely with the predicted value 17.06%.
  Irakoze Pierre Claver , Haihua Zhang , Qin Li , Huiming Zhou and Kexue Zhu
  The work consisted in optimizing steeping and germination condition and their effect on sorghum grain in term of malt loss, Soluble Solid (SS) yield, cold paste viscosity, amylase activity, tannin and protein content. The factors studied included steeping time and temperature with temperature and time of germination. Germination significantly affected the increase in malt loss, SS yield, amylase activity and protein content with a decrease in cold paste viscosity and tannin content of sorghum. Optimum conditions for sorghum were: steeping time for 24 h at 31oC and 4.5 d of germination at 30oC. Values predicted at optimum conditions by the response surface model for all responses were experimentally tested and close agreement between experimental and predicted values was observed.
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