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Articles by Qi Wang
Total Records ( 6 ) for Qi Wang
  Yongsheng Ma , Jennifer C. Pacan , Qi Wang , Yongping Xu , Xiaoqing Huang , Anton Korenevsky and Parviz M. Sabour
  This paper reports the development of microencapsulated bacteriophage Felix O1 for oral delivery using a chitosan-alginate-CaCl2 system. In vitro studies were used to determine the effects of simulated gastric fluid (SGF) and bile salts on the viability of free and encapsulated phage. Free phage Felix O1 was found to be extremely sensitive to acidic environments and was not detectable after a 5-min exposure to pHs below 3.7. In contrast, the number of microencapsulated phage decreased by 0.67 log units only, even at pH 2.4, for the same period of incubation. The viable count of microencapsulated phage decreased only 2.58 log units during a 1-h exposure to SGF with pepsin at pH 2.4. After 3 h of incubation in 1 and 2% bile solutions, the free phage count decreased by 1.29 and 1.67 log units, respectively, while the viability of encapsulated phage was fully maintained. Encapsulated phage was completely released from the microspheres upon exposure to simulated intestinal fluid (pH 6.8) within 6 h. The encapsulated phage in wet microspheres retained full viability when stored at 4°C for the duration of the testing period (6 weeks). With the use of trehalose as a stabilizing agent, the microencapsulated phage in dried form had a 12.6% survival rate after storage for 6 weeks. The current encapsulation technique enables a large proportion of bacteriophage Felix O1 to remain bioactive in a simulated gastrointestinal tract environment, which indicates that these microspheres may facilitate delivery of therapeutic phage to the gut.
  Xin Liu , Qi Wang and Liu-Ping Chen
  Recent studies show that the self-assembled monolayer (SAM) is well suited to control the selectivity of chemical vapor deposition (CVD). Here, we reported the selective CVD for copper on the functionalized SAM surfaces (with –SH, –SS–, and –SO3H terminal groups). The –SS– and –SO3H terminal group surfaces were obtained through in situ chemical transformation of –SH terminal group surface of a 3-mercaptopropyltrimethoxysilane-SAM (MPTMS-SAM). As a result, the –SS– terminal group surface reduces copper deposition and the –SO3H terminal group surface enhances copper deposition comparing to the –SH terminal group surface. In addition, the MPTMS-SAM was irradiated by UV-light through a photo mask to prepare SH-group and OH-group regions. Then, copper films were deposited only on the SH-group region of the substrate in chemical vapor deposition. Finally, patterns of copper films were formed in the way of UV-light irradiation. These results are expected for use of selective deposition of copper metallization patterns in IC manufacturing processes.
  Fengyu Zhu , Qi Wang and Zhengguang Shen
  Selection of Relevance Vector Machine (RVM) kernel function parameter is one among ineffectively resolved issues which is first resolved in the literature by Adaptive Particle Swarm Optimization (APSO). A novel APSO-RVM method is proposed to optimize and select the RVM kernel parameter, thus forming, taking the advantage of APSO dramatically convergence. Furthermore, the method is applied to the fault detection of liquid rocket engines test-bed. In order to verify the validity of dramatically effectiveness in fault detection, this paper demonstrates the proposed APSO-RVM approach by performing both simulations and experiments using Oxygen Valve Outlet Pressure (Pejy) data. Results show that APSO-RVM can rapidly detect faults effectively and has a high practical value.
  Zhengguang Shen , Qi Wang and Fengyu Zhu
  Aiming at the desired status self-validation of traditional multifunctional sensor, a novel multifunctional self-validating sensor functional model is proposed to improve the measurement reliability. Detailed self-validating functions are presented, especially the proposed health evaluation emphasized in this study. Being different from traditional fault diagnosis, it is improved from a quantitative perspective, in which a novel conception Health Reliability Degree (HRD) is defined to indicate the level. The HRD methodology is implemented by using the grey theory coupled with neural network-based multiple data fusion. The information entropy method is employed to obtain the weights distribution of each sensitive unit to indicate the distinct importance. A health evaluation experimental system of multifunctional self-validating sensor was designed to produce the actual samples and further verify the proposed methodology. Experimental results demonstrate that the proposed strategy could be used to indicate the health level quantitatively and provide a good solution to the health evaluation of multifunctional self-validating sensor.
  Wenjing Zhang , Haiting An , Feilong Zhang , Lin Dong , Qi Wang , Ruijun Su , Yanjing Qian and Xiaoli Gong
  Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the Substantia Nigra pars Compacta (SNc). There is no satisfactory therapeutic strategy for PD as yet. Here, triptolide (T10), a major active compound extracted from Tripterygium wilfordii Hook. f. (TWHF), a Traditional Chinese Medicine (TCM) used to treat autoimmune diseases, was found to significantly diminish the number of abnormal rotations induced by apomorphine in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model and protected DA neurons in SNc from 6-OHDA toxicity. Triptolide treatment was found to significantly suppress the activation of microglia and reduce the levels of oxidation products of proteins and lipids in the striatonigral systems of the PD model rats. Results suggest that triptolide might be a suitable lead compound in drug discovery for PD therapy.
  George Z. Cheng , WeiZhou Zhang , Mei Sun , Qi Wang , Domenico Coppola , Mena Mansour , LiMei Xu , Carliann Costanzo , Jin Q. Cheng and Lu-Hai Wang
  To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453-I4 with high invasive ability for gene expression and signaling pathways. We previously showed that the I4 lines had dramatically elevated levels of Twist compared with their parental lines. In this study, we observed significantly increased STAT3 Tyr705 phosphorylation, but not the STAT3 protein levels, in the I4 lines. Activation of STAT3 by interleukin-6 or expression of activated Src induced Twist expression at protein and mRNA levels. Inhibiting STAT3 by a small molecule inhibitor, JSI-124, STAT3 small hairpin RNAs, or dominant negative STAT3 resulted in significant reduction of Twist protein and mRNA expression. STAT3 directly bound to the second proximal STAT3-binding site on the human Twist promoter and activated its transcriptional activity. Inhibition of STAT3 reduced migration, invasion, and colony formation of the I4 cells. Ectopic expression of Twist significantly rescued those phenotypes. Ten normal and 46 tumor specimens of breast tissues were examined for activation of STAT3 and expression of Twist. There was a strong correlation between Tyr705 p-STAT3 and Twist level in the late stage tumor tissues. Our results indicate that activated STAT3 transcriptionally induces Twist, which plays an important role in promoting migration, invasion, and anchorage-independent growth. Together with our previous observation that Twist transcriptionally induces AKT2 to mediate Twist-promoted oncogenic functions, we conclude that STAT3, Twist, and AKT2 form a functional signaling axis to regulate pivotal oncogenic properties of cancer cells.
 
 
 
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