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Articles by Qamar Uddin Ahmed
Total Records ( 2 ) for Qamar Uddin Ahmed
  Abubakar Sule , Qamar Uddin Ahmed , Othman Abd. Samah , Muhammad Nor Omar , Norazian M. Hassan , Laina Zarisa M. Kamal and M. Ambar Yarmo
  Problem statement: Chronic disease-causing bacteria of medical importance have developed resistance to antibiotics, hence, necessitating distinct and constant need for safe and efficient therapeutic agents. Plants are considered potent candidate for this aim. A way out of reducing antibiotic resistance and adverse effects on host is the employment of antibiotic resistance inhibitors of plant origin. Approach: About 5 kg pulverized Andrographis paniculata whole plant was macerated with MeOH at room temperature to get 305 g freeze dried MeOH extract. The bioautography of MeOH extract using Staphylococcus aureus and Proteus mirabilis as indicator organisms revealed the presence of two potent antibacterial compounds. MeOH extract was further fractionated and purified by silica gel column chromatography which led to the isolation of a diterpene lactone and an ent-labdane diterpene glycoside upon crystallization with absolute ethanol. Results: Two antibacterial compounds viz., 3-O-β-D-glucosyl-14-deoxyandrographolide and 14-deoxyandrographolide were successfully isolated and characterized. Their structures were exclusively elucidated through spectroscopic methods (UV, IR, 1H- and 13C NMR). Conclusion: A. paniculata possesses antibacterial activity and could be potential source of a new class of antibiotics that might be useful for infectious disease chemotherapy and control.
  Abdul Viqar Khan , Qamar Uddin Ahmed , Athar Ali Khan and Indu Shukla
  Cycas rumphii is traditionally used to cure wide variety of ailments including malignant ulcers, wounds healing, sore throats and tuberculosis showing its great potential as an antimicrobial agent. Hence, aim of the present study was to explore antibacterial potential of the leaves of C. rumphii Miq. Dried leaves were separately macerated with methanol and double distilled water at room temperature to obtain methanol and aqueous (AQ) extracts. The methanol extract was further successively extracted with light petroleum ether (LPE), benzene (BZ), ethyl acetate (EtOAc) and methanol (MeOH) on hot water bath to get respective extracts. These extracts were evaluated for their antibacterial efficacy at six different concentrations (500 μg, 1, 2, 5, 10 and 15 mg mL-1) against seven G+ve and eleven G–ve hospital isolated bacterial strains causing several tropical diseases using disc diffusion method. EtOAc and MeOH extracts showed maximum antibacterial activity against most of the bacteria taken into account. The most susceptible Gram positive bacteria was S. albus with inhibition zone of 22 mm while most susceptible Gram negative bacteria was S. boydii with 21 mm inhibition zone with EtOAc extract while the most resistant bacteria was gram negative S. typhi. Present findings are suggestive of antibacterial agents in the leaves of C. rumphii which can be used in future for formulation of broad spectrum herbal antibacterial products. Results of present study also support various traditional uses associated with this plant which were suggestive of possible antibacterial potential of this plant. Hence, EtOAc and MeOH extracts of the leaves of C. rumphii deserve further investigations.
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