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Articles by Q. Zhang
Total Records ( 5 ) for Q. Zhang
  X Guo , X Xiao , S Li , P Wang , X Jia and Q. Zhang
 

Objective  To identify the genetic locus for X-linked nonsyndromic high myopia in a large Chinese family.

Methods  Phenotypic information and DNA samples were collected from 19 individuals in a Chinese family; 7 had high myopia and 12 were unaffected. We performed a linkage scan on the X chromosome and sequenced several candidate genes.

Results  High myopia in this family, presenting since early childhood and ranging from –6.00 to –15.00 diopters of sphere, is consistent with an X-linked recessive trait. The presence of a normal optic disc and the absence of color visual defects and other systemic abnormalities indicated that high myopia in this family is nonsyndromic. Our linkage analysis mapped the disease locus to Xq28, a 6.1-cM region between DXS8069 and Xqter, with 2-point logarithm of odds scores greater than 2.0 for 5 markers and a maximum logarithm of odds score of 3.59 at  = 0 for 2 markers. Sequence analysis of coding and adjacent intronic regions of GPR50, PRRG3, CNGA2, and BGN did not identify any potential causative mutation.

Conclusions  Nonsyndromic high myopia in a Chinese family was mapped to the MYP1 region, which confirmed and refined this region for high myopia. In addition, our results suggest that color visual defects and optic disc hypoplasia are not necessary signs of high myopia attributed to the MYP1 region.

Clinical Relevance  MYP1 is a common and the best locus for positional cloning of the gene responsible for high myopia. Our results suggest that MYP1 is also responsible for nonsyndromic high myopia.

  Y. Liu , X. Lu , J.G. Xu , Z.Q. Weng , W.X. Fu , Y.R. Luo , X.Y. Niu and Q. Zhang
  Interferon regulatory factor 7 (IRF-7) plays a crucial role in virus-induced activation of interferon-alpha/beta transcription and innate immunity. In order to evaluate its effect on cytokine traits in pig, IRF7 gene was chosen as a candidate gene to investigate in pig populations. SNP was identified by sequencing and PCR-RFLP method. Cytokine traits including IFN-γ and IL10 concentration in serum were measured when pigs were at the age of 20 and 35 days, respectively. The further association analysis between SNP genotypes and cytokine traits were conducted in three breeds including Large White, Landraces and Songliao Black, the later one is Chinese indigenous breed. The results indicated that the SNP of IRF7 gene had a highly significant effect on the level of IL10 (day 20) (p = 0.047), IFN-γ (day 35) in serum (p = 0.031) and the ratio of IFN-γ to IL10 (day 35) in serum (p = 0.035). The study suggested that IRF7 gene could be regarded as a molecular marker gene for genetic selection of cytokine traits in the further disease resistance breeding.
  Y. Liu , X. Lu , Y.R. Luo , J.P. Zhou , X.Y. Liu , Q. Zhang and Z.J. Yin
  In this study, IRF1 gene was chosen as a candidate gene to evaluate its effect on porcine cytokine traits in serum. A SNP in exon2 was demonstrated by sequencing and PCR-RFLP analysis. Cytokine traits include IFN-γ and IL10 concentrations in serum were measured when the pigs were at 20 and 35 days of age, respectively. The further association analysis between SNP genotype and cytokine traits were conducted in three pig breeds including Large White, Landraces and Songliao Black pig, one Chinese indigenous breed. The results indicated that the SNP of IRF1 gene had highly significant effect on level of IFN-γ (day 20; day 35) in serum (p = 0.0001; p = 0.0001) and ratio of IFN-γ to IL10 (day 35) in serum (p = 0.0083). The study suggested that the IRF1 gene could be regarded as a molecular marker gene for genetic selection of cytokine traits in the further disease resistance breeding.
  Y. Liu , Y.R. Luo , X. Lu , X.T. Qiu , W.X. Fu , J.P. Zhou , X.Y. Liu , Q. Zhang and Z.J. Yin
  In this study, haematological traits, lysozyme concentration and T lymphocyte subpopulation as markers of innate immunity were detected and compared among Landrace, Large White and a chinese indigenous breed, Songliao Black pig. The animals were of the same age and kept under the same environmental conditions to reduce non-genetic variation in immune traits; they were all apparently healthy and were vaccinated by CSF live vaccine at 21 days of age. Except LY%, MO%, CD4CD8% and RDW, the other detected immune traits were significant difference between before (20 days) and after vaccination (35 day). While the values of MCV, MCH, MCHC, MO%, CD4+CD8+% and CD4+CD8+/CD4CD8+ values decreased after vaccination, the others increased. The values of WBC, GR, LY, MO, CD4+CD8% and CD4+CD8+% were significant difference among Large White, Landrace and Songliao Black pig (p<0.05). Our analysis confirms that Songliao Black pig has better innate immune level than Landrace and Large White. The animal resource population was suggested to be appropriate to investigate further the QTL and genes contributing to differences on these innate immune traits in pigs.
  Z Huang , M Chen , K Li , X Dong , J Han and Q. Zhang
 

Cryo-electron tomography was employed to reconstruct the structure of Chlamydia trachomatis. Results revealed that the features of the structures, especially those of the membranes, were preserved much better than those by conventional ultrathin section methods. This method also enabled us to determine that the thickness of the outer membrane of the elementary bodies is nearly twice of that of the reticulate bodies. Our observations give a clue to the mechanism of outer membrane changes.

 
 
 
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