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Articles by Q. Li
Total Records ( 5 ) for Q. Li
  H Jiang , Y Zhu , H Xu , Y Sun and Q. Li
 

Accumulating data suggested that hypoxia inducible factor (HIF)-1 plays an important role in the evolution and propagation of the inflammatory process. To characterize the activation of HIF-1 in rats with chronic obstructive pulmonary disease (COPD) and examine the possible role of nuclear factor (NF)-B in this process, rats were challenged by introtracheal instillation of lipopolysaccharide (LPS) and exposure to cigarette smoke. Pyrrolidine dithiocarbamate (PDTC) was administered via the oral route 1 h before LPS or cigarettes administration. Four weeks later, pulmonary function and histology were tested; bronchoalveolar lavage fluid (BALF) and arterial blood gases were assayed. Activation of pulmonary NF-B was assessed by quantitative PCR, immunoblot analysis, and electrophoretic mobility shift assay, respectively. Results showed that LPS and smog induced the characteristics of COPD seen in human. PDTC alleviated the development of COPD and the levels of cytokines in BALF of PDTC+COPD group were significantly decreased compared with that of COPD group. The activation of pulmonary NF-B was inhibited by PDTC and the accumulation of HIF-1 gene expression in the COPD group was attenuated by PDTC pretreatment. Furthermore, the mRNA levels of HIF-1 target genes heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) were parallel to the attenuation of HIF-1 by PDTC. These findings indicated that the activation of HIF-1 pathway via NF-B contributes to the development of COPD, and administration of NF-B inhibitor may attenuate the development of COPD.

  R Ning , X Zhang , X Guo and Q. Li
 

Nuclear factor kappa B (NF-B) plays a prominent role in the pathogenesis of infectious diseases. Staphylococcus aureus (S. aureus), which can attach to and invade human osteoblasts, is the most common causative agent of osteomyelitis. To determine whether S. aureus can activate NF-B in human osteoblasts and explore the possible factors of activation in response to infection, we used flow cytometry, enzyme-linked immunosorbent assay, immunoblots, and electrophoretic mobility shift assays to quantify the invasion of bacteria, to measure the interleukin-6 (IL-6) of culture supernatants, and to investigate the IB degradation and NF-B activation in human osteoblasts. Moreover, we explored the possible factors responsible for the activation of NF-B by preventing S. aureus from physically touching human osteoblasts or inhibiting the invasion of S. aureus into human osteoblasts under co-culture conditions, by incubating proteinase K-treated or ultraviolet-killed S. aureus with human osteoblasts and by treating human osteoblasts with peptidoglycan (PGN) or lipoteichoic acid (LTA). We found that S. aureus induced the IB degradation and NF-B activation, which could regulate IL-6 secretion in the culture supernatants of human osteoblasts in response to infection. In addition, the maximal IB degradation and NF-B activation in human osteoblasts occurred prior to the maximal invasion of S. aureus. It was the attachment not invasion or the secreted soluble factor(s), PGN, LTA of S. aureus, that could induce the IB degradation and NF-B activation in human osteoblasts. These results indicated that S. aureus can activate NF-B in human osteoblasts and that the attachment of S. aureus is required for this activation in response to infection.

  L. Chen , Q. Li , Z. Yang , Z. Ye , Y. Huang , M. He , J. Wen , X. Wang , B. Lu , J. Hu , C. Liu , C. Ling , S. Qu and R. Hu
  Aim  To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.

Methods  We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.

Results  Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (< 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (= 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (= 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (> 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (= 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both < 0.05).

Conclusions

  M. J. Zaman , A. Patel , J. Chalmers , M. Woodward , P. Clarke , Q. Li and S. Zoungas
 

Aims

The ADVANCE trial recruited participants from 20 countries worldwide. We analyse here regional variations and causes of hospitalization for people with Type 2 diabetes from Asia, Established Market Economies and Eastern Europe.

Methods

A cohort analysis examining the effects of region on causes of first hospitalization, and the association of participant characteristics on all-cause first hospitalization across regions, using multivariable (adjusted for clinical, physiological, behavioural and socio-demographic factors) Cox models.

Results

Of 11 140 individuals (6407 men), all-cause hospitalization rates were highest in Established Market Economies, followed by Eastern Europe then Asia. Eastern Europe had rates of hospitalization for diabetic causes four times greater than Established Market Economies [multivariable-adjusted hazard ratio 4.02 (95% CI 2.86-5.63)]. There were no significant regional variations in hospitalization rates for cardiovascular disease (P = 0.534), but much lower rates for musculoskeletal and non-specific causes in Eastern Europe [multivariable-adjusted hazard ratio 0.44 (95% CI 0.32-0.60) and 0.19 (95% CI 0.12-0.29)] and Asia [hazard ratio 0.21 (95% CI 0.16-0.29) and 0.09 (95% CI 0.06-0.14)] compared with Established Market Economies. In all regions, participants hospitalized for any cause were more likely to be older, male, hypertensive, smokers, have higher glycated haemoglobin and a history of macrovascular or macrovascular disease.

Conclusions

Across three markedly different regions of the world, regional rates and causes of hospitalization varied widely in patients with Type 2 diabetes. Adjustment for a range of patient characteristics did not explain these regional differences in hospitalization, which appear to be attributable to health system factors.

  M. Williams , A.N. Nechaev , M.V. Lototsky , V.A. Yartys , J.K. Solberg , R.V. Denys , C. Pineda , Q. Li and V.M. Linkov
  A pre-treatment technique was developed to facilitate electroless deposition of palladium layers on the surface of metal hydride-forming alloys for increasing hydrogen absorption kinetics. The technique involved functionalization of the oxidized surface of the alloys by deposition of assembled layers derived from δ-aminopropyltriethoxysilane. This results in the formation of a surface assembly of adhesive functional groups for the immobilization of palladium as a unique catalyst for hydrogen sorption. The layers of δ-aminopropyltriethoxysilane aided immobilization of Pd nuclei, in the activation procedure of electroless deposition, by increasing the chemical adhesion. Pd electroless deposition on rare-earth metal hydride-forming alloys, without δ-aminopropyltriethoxysilane pre-treatment, facilitated the deposition of Pd agglomerates, whereas the use of δ-aminopropyltriethoxysilane pre-treatment facilitated the deposition of continuous Pd layers on the surface of the alloy resulting in dramatic improvements in hydrogen sorption performances, including faster kinetics of hydrogenation of the non-activated material under mild conditions, compared to that observed for non-activated unmodified starting materials and materials surface modified by Pd electroless deposition without the additional δ-aminopropyltriethoxysilane pre-treatment step. The attractiveness of aminosilane pre-treatment for improvement of hydrogen sorption properties of rare earth–nickel-based AB5 alloys, and the influence of the differences in surface structure between deposited Pd agglomerates and layers was demonstrated.
 
 
 
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