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Articles by Q. Hasan
Total Records ( 4 ) for Q. Hasan
  F. B. Aziz , M. A. Awal , Q. Hasan and M. M. Rahman
  Ectoparasites are distributed all over the world but occur mainly in tropical and sub-tropical countries. Ectoparasites result in a considerable amount of blood loss, disturbances in feeding, retarded growth and decreased production. Among the ectoparasiticides ivermectin is a new endectocide and diazinon is another commonly used ectoparasiticide available in Bangladesh. The present research was designed to study the comparative efficacy of ivermectin and diazinon against ectoparasites, their effects on some clinical, hematological and biochemical parameters in sheep. For this purpose 25 sheep heavily infested with ticks and lice were randomly divided into 5 equal groups, i.e. groups B, C, D, E and F. Another group of 5 sheep free from parasitic infestation were also selected and kept as uninfected control (group A) and group B was kept as infected control group. The sheep of groups C and D were treated with recommended (200 g/kg b.w.) and higher than recommended (300 g/kg b.w.) doses of ivermectin subcutaneously. The sheep of groups E and F were treated with diazinon (spray) at recommended (0.1% soln.) and higher than recommended (0.2% soln.) doses. After injection of ivermectin and spray of diazinon all four treated and two groups were kept for 28 days and clinical, hematological and biochemical parameters were investigated at 7 days intervals. The data were collected and analyzed statistically between control and treated groups by using student ‘t` test . On the basis of lice and tick count, the efficacy of ivermectin was found 100% whereas diazinon was 82-85% effective against ectoparasitic infestation in sheep. Ivermectin and diazinon increased the feeding efficiency as compared to infected control groups. No adverse effects was observed following both the dose of ivermectin and recommended dose of diazinon. In this study, the hematological parameters, i.e. TEC and Hb% were increased significantly (p<0.01) in all treated four groups to the extent of 35-70% and 10-21% respectively. On the other hand, ESR values were decreased significantly (p<0.05). No significant change was observed on SGOT and SGPT following both the doses of ivermectin injection. However, SGOT and SGPT values were significantly (p<0.01) increased to the extent of 46-90% and 25-46% within 7-14 days of diazinon spray. However, elevated values of SGOT and SGPT became almost normal within 28 day of treatment. Among the recommended and higher than recommended doses of ivermectin and diazinon, the recommended dose of both the drugs is suitable for therapeutic purpose. Among the two drugs, ivermectin was found to be the best drug against ectoparasites showing prompt and 100% efficacy.
  P. K. Das , M. Mostofa , Q. Hasan , G. C. Shil and M. R. Islam
  The research work has conducted in 4 groups (each containing of 5 mice) of swiss albino mice following oral administration of H2-blockers and proton pump inhibitor (Ranitidine, Famotidine and Omeprazole) at the dose rate of 100 mgkg-1. b. wt. 13.33 mgkg-1. b. wt. and 3.33 mgkg-1 b. wt., respectively to investigate the toxic as well as gross pathological changes and also to estimate the blood glucose level. Loose faeces were found in group B (Ranitidine) during last few days of experimental period. Following post-mortem examination, congestion and pale colour of the liver was found in group C and D respectively. In the treatment group B (Ranitidine), TEC, TLC, Hb%, Monocyte, Neutrophil and Eosinophil count were significantly decreased whereas Lymphocyte was significantly increased in the same treatment group. The highest decrease in TEC (16.08%), TLC (17.77%), Hb% (20.75%), Monocyte (33.33%), Neutrophil (26.31%), Eosinophil (33.33%) was recorded. In the treatment group C (Famotidine), TLC, Monocyte count, blood level serum were significantly decrease whereas Lymphocyte count was significantly increased in the same treatment group. The highest decrease of TLC (17.41%), blood glucose (36.67%), Monocyte count (41.66%) was recorded. The highest increase of Lymphocyte was also recorded. In the treatment group D (Omeprazole), TLC, Monocyte count, blood glucose level were significantly decreased whereas Lymphocyte and neutrophil count was significantly increased. The highest decrease of TLC (23.28%) and Monocyte count was also recorded.
  B.C. Basak , M.A. Awal , Q. Hasan , M.M. Rahman , M.A. Jalil and M.A.Q. Miah
  A research work was undertaken following oral doses of doxycycline and calcium with feed for 35 days from January to March, 2002, to study the adverse effect, hematological parameters, serum calcium level and post mortem changes in five groups (A, B, C, D and E) of Swiss albino mice (n=25). Among these groups of mice group A was kept as control. Group B was treated only with doxycycline @ 500 mg kg-1 feed but groups C, D and E was given calcium @ 400 mg, 800 mg & 1200 mg kg-1 feed respectively in addition to doxycycline @ 500 mg kg-1 feed. All the treated groups of mice showed clinical signs like roughness of the body, depression, anorexia, weakness, staggering gait, recumbency at latter stage of the study period but these clinical signs were mild in calcium supplemented groups of mice. No visible adverse effect found in the offspring of any group of mice. Administration of doxycycline resulted significant decrease in total erythrocyte count (TEC), hemoglobin content (Hb%), percentage of neutrophil count & serum calcium level in all treated mice but calcium supplementation gradually improved these results in groups C, D & E respectively. Following post mortem examination, all the visceral organs were found to be highly congested and blood was blackish in colour in group B whereas mild or no congestion was found in calcium supplemented group, i.e., groups C, D & E. From the findings of the present study it may be concluded that long term administration of doxycycline results adverse effects as well as decrease serum calcium level. So, when doxycycline is to be administered for long period of time supplementation of calcium should be considered simultaneously.
  M.M. Haque , K. Rafiq , S.J. Sherajee , S. Ahmed , Q. Hasan and M. Mostofa
  The present investigation was carried out in 40 guinea pig with the aim to investigate the efficacy of some indigenous medicinal plants in the treatment of external wounds. Two wounds of 2.00 cm length and 0.5 cm depth were made on the opposite thigh muscles and the effects of some antibacterial and some indigenous medicinal plants leaves were observed separately. Among the antibacterial used in this studies comparatively Nebanol powder showed the best result and was more effective for the treatment of fresh wounds in which healing occurred with in 11 days, Where as it was taken 13 days for sulfanilamide powder and 15 days for dusting powder treated groups. In the present experiment the leaves of the Neem, Ganda, Mehedi and raw Halid were applied as fresh aqueous pastes for the treatment of artificially produce wound in guinea pig. In comparison to their effect, Neem leaves paste showed the more effectiveness where healing was completed on 15 days, Halud paste and Ganda leaves pastes showed the same results, where healing was completed on 17 days. The Mehedi paste was the least effective in which healing occurred on 19 days. This investigation suggested that Neem leaves fresh paste are more effective for wound healing in guinea pig which may be suggested for the treatment of fresh wound healing of other livestock.
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