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Articles by Q Du
Total Records ( 2 ) for Q Du
  Q Du , L Ju and L. Tian
 

In this paper, we study a finite-volume method for the numerical solution of a model fourth-order partial differential equation defined on a smooth surface. The discretization is done via a surface mesh consisting of piecewise planar triangles and its dual surface polygonal tessellation. We provide an error estimate for the approximate solution under the H1-norm on general regular meshes. Numerical experiments are carried out on various sample surfaces to verify the theoretical results. In addition, when the underlying mesh is constructed by the so-called constrained centroidal Voronoi meshes, we propose a numerically demonstrated superconvergent scheme to compute gradients more accurately.

  W Cao , L Bover , M Cho , X Wen , S Hanabuchi , M Bao , D. B Rosen , Y. H Wang , J. L Shaw , Q Du , C Li , N Arai , Z Yao , L. L Lanier and Y. J. Liu
 

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7–FcRI complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC’s IFN responses through ILT7 in a negative feedback fashion.

 
 
 
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