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Articles by Purbajit Chetia
Total Records ( 1 ) for Purbajit Chetia
  Purbajit Chetia , Asis Bala , Bidita Khandelwal and Pallab Kanti Haldar
  Background: β-carotene and naringenin are two plant derived molecules which posses antioxidant property. Naringenin is the predominant flavanone found in grape fruit. β-carotene is a natural fat-soluble pigment found principally in plants. Beta-carotene is converted by the body into vitamin A and acts a powerful antioxidant and helps support the immune system. Objective: Present studies were performed to compare the free radical scavenging property of β-carotene and naringenin with respect to vitamin C and N-acetyl cysteine which are the synthetic compounds and posses the potent antioxidant property. Materials and Methods: Various biochemical assay like DPPH, hydroxyl radical, nitric oxide and superoxide scavenging activity test were carried out by considering different concentration of the compounds. Results: It was found that β-carotene and naringenin showed a remarkable capacity to scavenge all the tested reactive species in a dose dependent manner and all the IC50 values (Mean±SEM) for three individual experiments being found at the μg mL-1 level (66±2.34-84.99±2.84 μg mL-1) which was comparable to synthetic compound vitamin C and N-acetyl cysteine. vitamin C and N-acetyl cysteine was a well established synthetic antioxidant used in different inflammatory disorder however, the prohibitive synthesis cost of these drugs coupled with the need for long-term therapy results in a high frequency of side-effects, making it imperative for better and safer drugs to be made available. So we are hopeful that naturally occurring antioxidant can also be a replacement for treatment of free radical mediated inflammatory diseases.
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