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Articles by Pratibha Singh
Total Records ( 5 ) for Pratibha Singh
  Harendra Singh , Pratibha Singh , R.P. Singh and Mritunjay Tripathi
  Health promoting biochemical parameters of 15 distinct chickpea genotypes (Desi and Kabuli) showed wide variability in their chemical composition, crude fiber, total mineral content, total free amino acid Rhizobium inoculated was relatively higher than non inoculated. Reducing sugar, non reducing sugar, total sugar non inoculated was relatively higher than Rhizobium inoculated. Crude fibre content in chickpea ranged from 12.89-13.79% in control, Rhizobium inoculated 13.11-15.03%, total mineral content ranged from 3.55-3.79% in control, Rhizobium inoculated 4.14-4.45%, total free amino acids in chickpea seeds ranged from 2.35-2.51% in control, Rhizobium inoculated 2.38-2.65%, reducing sugar content in chickpea seeds ranged from 24.45-25.80% in control, Rhizobium inoculated 24.05-25.38%, non reducing sugar content in chickpea seeds ranged from 39.06-41.21% in control, Rhizobium inoculated 38.41-40.53%, total sugar content in chickpea seeds ranged from 63.51-67.00% in control, Rhizobium inoculated 62.46-65.91%. The research result about the biochemical characteristics of control and Rhizobium inoculated chickpea genotypes are expected to provide guidelines for the researches confronted with the need to use such typical food seed in India as well as in the rest of the world.
  Mritunjay Tripathi , Pratibha Singh , Praveen Pandey , Vankat R. Pandey and Harendra Singh
  This experiment has been conducted to study antioxidant activities and biochemical changes in round as well as long cultivars of brinjal. Results showed that maximum protein content, amino acids, important minerals (Ca, P, K) and crude fibres were recorded in Pusa Purple Round Pusa Purple Long. Maximum phenolic content of brinjal fruit in round varieties was obtained in Pusa Purple Round followed by Pant Rituraj and NDBH-1 (86.13 mg/100 g). Phenolic content was maximum in Pusa Purple Long followed by Pusa Kranti and NB-2 in long varieties and Pusa Purple Round in round varieties. A linear relation between the total phenolic content and DPPH activities of the extracts was observed. Antioxidant activity of brinjal fruit was noticed between (182.01-234.13 μg) in round varieties and (172.11-219.92 μg) in long varieties. Maximum antioxidant activity of brinjal fruit in round varieties was obtained in Punjab Bahar followed by Pusa Purple Round and NB-1. However in long varieties of brinjal fruit it was maximum in NDBH-2 followed by Pusa Purple Long and NB-1. While, lowest activity was recorded in round variety NDBH-1 and Pant Samrat in long variety. On the basis of biochemical investigation, it can be concluded that brinjal is very nutritive and useful vegetable because it is rich source of protein, minerals, crude fibre, phenolic content, antioxidant activity and important essential amino acids.
  Harendra Singh , Pratibha Singh , R.P. Singh and Mritunjay Tripathi
  Fifteen genotypes of chickpea control and Rhizobium inoculated were investigated for protein content and genetic divergence based on seed protein profile using Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE). Protein content of desi type was relatively higher than kabuli type. Protein content fifteen genotypes ranged from 18.76-23.58% in control, Rhizobium inoculated 19.83-24.54%. Desi and Kabuli genotype of chickpea Rhizobium inoculated gave some unique band in comparison to control genotype of chickpea. Desi genotypes gave some unique band in comparison to Kabuli genotypes of chickpea. Highest number of protein band found in PUSA 362, KWR 108 and followed by H82-2 and Phule G 5 whereas minimum number of protein bands were found in L550. It is clear from the result obtained that the chickpea genotype having highest number of protein band having highest quantity of protein. Maximum bands are of medium molecular weight followed by highest molecular weight and low molecular weight. Electrophoresis (SDS-PAGE) of seed storage protein can economically be used to assess, genetic variation and relation in genotypes. Thus, specific bands of seed storage protein profile may be used as markers for identification of the mutants/genotypes. The research results about the biochemical characteristics of desi chickpea varieties are expected to provide guidelines for the researchers confronted with the need to use such typical food seeds in India as well as in the rest of the world.
  Pratibha Singh , Neetu Singh and Gautam Palit
  Back ground: Gastro Esophageal Reflux Disease (GERD) is a common disorder, affecting approximately 10-20% of the western population and often has a debilitating effect on the daily lives of patients. Result: GERD can be described as any symptomatic condition or histopathologic alternation resulting from episodes of gastroesophageal reflux. Transient relaxation of the lower oesophageal sphincter is believed to be the primary mechanism of the disease although the underlying cause remains uncertain. GERD usually manifests as heartburn, regurgitation, or dysphagia and predisposes to development of esophagitis, stricture, Barrett’s metaplasia, esophageal adenocarcinoma. The various agents currently used for treatment of GERD include proton pump inhibitors, antacids, H2-blockers, mucoprotective substances and prokinetic agents. Conclusion: This review gives an overview of the pharmacological management of GERD and summarizes the state of the art with these agents.
  Neetu Singh , Pratibha Singh , Gautam Palit and Vijai Lakshmi
  Aim: Preliminary study revealed that gedunin and photogedunin, from Xylocarpus granatum exhibit anti-ulcer property. In an attempt to clarify the mechanism involved in its anti-ulcerogenic potential, an advanced studies to examine their effects on potent gastric acid secretagogues i.e., plasma gastrin and gastric mucosal histamine in pyloric ligation induced ulcer model. In addition, an evaluation of the cytoprotective function of these compounds by assessing the gastric PGE2 levels in alcohol induced gastric ulcer model. Methods: Adult Sprague Dawley rats, weighing 180-220 g procured from National Laboratory Animal Centre, CDRI, were used in the study. Rats were housed three to four per cage, in a room with temperature regulated at 22±2°C, with a 12 h/12 h light/dark cycle (lights on 07:00 h, lights off 19:00 h). Standard chow pellets and water were given ad libitum, except during the period when food deprivation was applied. Compounds of Xylocarpus granatum and standard drugs like omeprazole (10 mg kg-1) and sucralfate (500 mg kg-1) were prepared in 1% carboxymethyl cellulose (CMC) as suspension and administered orally 45 min prior to exposure of ulcerogens to the animals at a volume of 1 mL/200 g of body weight. All animals were deprived of food for 16 h before ulcerogens exposure and were divided into three groups, (n = 6). Control group of animals were treated with vehicle 1% CMC. Compound gedunin and photogedunin (20 mg kg-1, p.o.) were tested against alcohol and pyloric ligation induced gastric ulcer model. Standard anti-ulcer drugs, omeprazole (10 mg kg-1, p.o.) were treated in pyloric ligation model and sucralfate (500 mg kg-1, p.o.) in alcohol induced ulcer model. Results: Gedunin and photogedunin exerted significant acid lowering activity in pyloric ligated rats as evident through reduced free acidity and total acidity as well as in vitro H+K+-ATPase activity. Also, both compounds normalized the plasma gastrin and tissue histamine level compared to ulcerated rats. Contrastingly, both compounds illustrated no significant increase in gastric PGE2 level and mucin content compared to ulcer control rats. Conclusion: Thus, the study suggested that gedunin and photogedunin imparts gastro-protection through antisecretory mechanism.
 
 
 
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