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Articles by Pranveer Singh
Total Records ( 2 ) for Pranveer Singh
  Ram Sewak Kachhi , Vikas Kumar Saket , Poonam Sharma and Pranveer Singh
  Background and Objective: Tribals in Amarkantak region of Madhya Pradesh district owing to abject poverty, illiteracy avoid taking modern allopathic treatment for tuberculosis and resort to occult/hokum that aggravates the disease making them potential reservoir of infection. Materials and Methods: Present study has employed the novel concept of combining the best of modern TB diagnostics with traditional herbal medicine system for TB treatment. The study has enrolled over hundred cases of uncured TB and also the relapse cases across different age groups, gender and status over the period of 2 years. Results: The outcome has validated the efficiency of proposed model of treatment as patients were completely cured of TB without significant relapse cases. Additionally, it has multitude of benefits including economy of cost involved and lack of any potential side effects. Traditional system of medicine has proven itself to be a robust system for TB treatment with multitude of benefits. Conclusion: The findings from many more similar studies may pave the way for adopting such model of treatment. This will ease the economic burden on the government exchequer by reducing the cost of the treatment and will increase the cultivation and conservation measures of medicinally important plants.
  Pranveer Singh
  Protein-protein, protein-ligand and protein-lipid interactions are fundamental to most of the physiological processes. Membrane proteins are particularly very important in this regard as most of the marketed drugs and those under clinical trials target these proteins either activating or inhibiting their activity thus reflecting their importance in human health and disease. This perceived importance warrants the detailed analysis of the process to understand and elucidate the underlying mechanisms behind the process. However, there are significant constraints like lack of high resolution structure, difficulty in getting the sufficient amount of purified protein and crystallization. The advancement in surface chemistry, coupled with modified sensor chips with improvised surface chemistry where lipid bilayer can be created thus, mimicking the native membrane environment have greatly facilitated and revolutionized the kinetic and equilibrium analysis of such interactions. Additional advantages offered by plasmon resonance based techniques include, high sensitivity, accuracy, label free analysis, lesser protein requirement etc. This review highlights the membrane protein interactions with their specific ligands with special emphasis on G-Protein Coupled Receptors (GPCRs), optimized protocols to study such interactions, associated challenges and advantages and disadvantages of each protocols and finally future road map of such studies.
 
 
 
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