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Articles by Pooneh Salari
Total Records ( 4 ) for Pooneh Salari
  Pooneh Salari and Mohammad Abdollahi
  The relationship between cardiovascular diseases (CVD) and osteoporosis two common disease in aged people has been theorized since several years ago but many controversies exist yet. In this study, the role of inflammatory cytokines in both diseases has been studied in depth. In the pathophysiology of diseases, estrogen deficiency (in women), oxidative stress, vitamin K deficiency, vitamin D overload, secondary hyperparathyroidism, hyperhomocysteinemia and inflammation play substantial role. Meanwhile, drug therapy of each disease may affect the other one, a spectacle potentiating the common inflammatory link theory. Results of this review indicate that cytokines or proteins such as interleukin (IL)-1, IL-6, IL-11, IL-12, IL-15, IL-17, tumor necrosis factor-α (TNF-α), interferons, macrophage colony stimulating factor (M-CSF), granulocyte M-CSF (GM-CSF), receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), osteopontin (OPN), osteonectin, bone morphogenic proteins (BMPs), bone morphogenic protein-2 (BMP-2), transcription factor for osteoblasts differentiation (Runx2), C-reactive protein (CRP), cyclooxygenase (COX), oxidized LDL, paraoxonase, lysosomal cysteine protease cathepsin K and platelets are shared in the pathophysiology of both diseases. Accordingly, drugs such as bisphosphonates, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors known as statins, non-steroidal anti-inflammatory drugs (NSAIDs), anti-platelet drugs such as clopidogrel or ticlopidine and phytoesteroges affect conditions of both diseases. The inflammatory elements sharing in pathogenesis of both CVD and osteoporosis lead us to revise developments of new drugs in this specific area of science that is much relevant to the health of elderly people who are increasing in developed world.
  Pooneh Salari
  Not Available
  Pooneh Salari
  Not available
  Pooneh Salari , Shekoufeh Nikfar and Mohammad Abdollahi
  Recently, exenatide as an incretin mimetic was approved by FDA as an adjunct to diet and exercise in treating type 2 diabetes. Therefore comparing every new medication with insulin can provide more clues about the real benefit of paying extra budget for new drugs. In this meta-analysis we compared the efficacy and tolerability of exenatide to insulin. The literature search provided 1016 articles while only 5 articles were eligible to be included in the meta-analysis with a total of 1404 patients enrolled in the study. The results show that there is no superiority for exenatide over insulin even in its weight reduction advantage. However, the high risk of gastrointestinal side effects including nausea and vomiting is of major concern. Current evidence does not support the advantage of exenatide over insulin but more clinical trials are needed to reach a convincing conclusion.
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