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Articles by Piyush Trivedi
Total Records ( 2 ) for Piyush Trivedi
  Garvita Chaudhary , C. Karthikeyan , N.S. Hari Narayana Moorthy and Piyush Trivedi
  Quantitative Structure Activity Relationship (QSAR) studies were performed on some tubulin-binding agents. The compounds in the selected series were characterized by topological and Approximate Surface Area descriptors calculated using QuaSAR module of Molecular Operating Environment (MOE). Significant equations were derived from regression analysis shows significance of different descriptors contributing towards the cytotoxic activity. The results of the study show that cytotoxic activity of diarylsulphonylurea can be successfully explained in terms of topology of the molecule. VSA_don contribution towards the activity indicates molecules capable of hydrogen bonding will be beneficial for tubulin polymerization inhibitory activity. Another descriptor contributing beneficially to the cytotoxic action of diarylsulphonylurea is SMR_VSA5. SMR deals with polarizibility; hence increasing polarizibility will increase cytotoxic activity. Negative contribution of a_nN descriptor to the biological activity, signifies that the introduction of nitrogen should be kept minimum while designing new cytotoxic diarylsulphonylurea compounds. The negative coefficient of the descriptor Wiener Path suggests that increased branching in the side chain and resultant decrease in its flexibility is conducive for cytotoxic activity.
  C. Karthikeyan , Dengale Santosh , N.S. Hari Narayana Moorthy and Piyush Trivedi
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