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Articles by Ping Li
Total Records ( 10 ) for Ping Li
  Bing Xu , Shaolin Wang , Yan Jiang , Linlin Yang , Ping Li , Caixia Xie , Jubin Xing , Zhonghe Ke , Jiale Li , Junwei Gai , Guimei Yang , Baolong Bao and Zhanjiang Liu
  Grass carp, Ctenopharyngodon idellus (Valenciennes, 1844), is an economically important species widely cultured in the world, but its genome research resources are largely lacking. The objectives of this study were to construct normalized cDNA libraries for efficient EST analysis, to generate ESTs from these libraries, and to identify EST-related molecular markers such as microsatellites and single nucleotide polymorphisms (SNPs) for genetic analysis of this species. A total of 6,269 ESTs were generated representing 4,815 unique sequences, from which 105 putative microsatellites and 5,228 SNPs were identified. These genome resources provide the material basis for future genetic and functional analyses in this species.
  Ping Li and Fujiang Jin
  In this study, the problem of Fault-Tolerant Control (FTC) for a class of uncertain nonlinear systems is studied. A novel FTC scheme is proposed to deal with both lock-in-place and loss of effectiveness faults of actuators. By employing fuzzy approximation and on-line adaptive updating, the proposed control scheme can tolerate the faults without detection and diagnosis mechanism. It is proved in theory that the FTC scheme can guarantee the closed-loop stability and desired output tracking performance in spite of all kinds of the faults and external disturbances. A simulation example is also included to show the effectiveness of the scheme.
  Ping Li and Xiaoyu Shu
  Background and Objective: Acute and chronic gastritis both possess dyspeptic symptoms. The objective of present study was to explore the effect of zerumbone on the acute or chronic gastritis. Materials and Methods: The study was divided into three different groups of 220 patients each. Zerumbone with hydroxypropyl-β-cyclodextrin the inclusion complex was prepared by the freeze-drying method. All patients of vehicle group, treatment group and control group were injected with 2 mL Water For Injection (WFI), 2 mL solution containing 20 μM doses of zerumbone and 0.15 g ranitidine capsule taken orally, respectively for 20 days. All patients were analyzed by gastric endoscopic examination. The biopsies of gastric tissue were made to perform the histopathological study and urea breath tests. The one-way ANOVA/the Dunnett’s multiple comparison tests were used for significant difference of scores at 95% level of confidence. Results: Zerumbone treatment was prevented epigastric pain, nausea, anorexia, vomiting and inflammation of gastric mucosa after 20 days of treatment (p≤0.05 for all parameters). Numbers of patients with infection of Helicobacter pylori were 22 and 2 (p≤0.05) for before and after zerumbone treatment. Conclusion: Zerumbone treatment was quite effective and safe in acute and chronic gastritis with or without Helicobacter pylori infection Clin.
  Guangsheng Xi , Jianing Wang , Ping Li , Yugang Gao , Shengxue Zhou and Yunjia Wang
  Background and Objective: The low capacity of body in the absorption of ginsenosides presents an important question as how to effectively improve absorption, which remains a subject of broad and current interest among researchers. This study aimed to investigate the effects of compound amino acids and ginsenosides on the visceral organ index and blood lipid profile and to assess the absorption rate of ginsenosides and amino acids. Materials and Methods: Male iCR mice were randomly assigned to 7 groups (12 mice/group): Group i (saline control), Group ii (ginseng), Group iii (composite ginsenosides), Group iV (compound amino acids), Group V (amino acids and ginsenosides, high dose), Group Vi (amino acids and ginsenosides, middle dose) and Group Vii (amino acids and ginsenosides, low dose) who were treated with the corresponding drugs by gavage for 4 weeks. Weight, visceral index, blood lipid profiles and absorption rates of the mice were then analysed and compared using one-way ANOVA. Results: The middle dose of compound amino acids and ginsenosides increased the body weight of the mice without influencing the liver, lung, kidney, testis, spleen or thymus indexes (p>0.05). Compound amino acids and ginsenosides reduced blood lipid levels, including CHO, TG, HDL-C and LDL-C. HPLC and amino acid analyses revealed that compound amino acids could significantly improve p<0.05 the absorption rate of ginsenosides in mice (p<0.05), especially in the middle-dose group. Conclusion: Supplemental compound amino acids may be helpful for ginsenoside uptake by visceral organs. in addition, the beneficial effects of ginsenosides include body weight increase and blood lipid reduction.
  Jun-Ge Wang , Qiu-Ping Zhou , Guo-Fang Zhang , Ping Li , Bao-Hua Chen , Feng-Qi Zhao , Ji-Zhen Li and Xue-Zhong Fand
  Three neodymium compounds, Nd(4DNP)3(C2H5OH)3 (1), Nd(4DNPO)3 · 7H2O (2), and {[Nd(μ-ox)(4DNPO)(H2O)4] · 4H2O}n (3) (4HDNP, 3,5-dinitropyrid-4-one; 4HDNPO, 3,5-dinitropyrid-4-one-N-hydroxide; ox, oxalate), were synthesized and characterized by FT-IR, elemental analysis, thermogravimetry-differential scanning calorimetry (TG-DSC), and two of them by single-crystal X-ray diffraction analyses. The results revealed that in 1, the Nd(III) is surrounded by three chelating ligands and three ethanol solvent molecules. The structure of 3 could be described as 1-D chains in which Nd is bis-bidentately bridged by oxalates, together with a monodentate 3,5-dinitropyrid-4-onate N-oxide 4DNPO ligand and four water molecules as well as four uncoordinated water molecules in the crystal lattice. The origin of the oxalate anions in 3 is probably due to decomposition of the 4DNPO or its oxidation of other species. The TG-DTG (DTG, derivative thermogravimetry) and DSC analyses showed that 1 underwent a three-stage decomposition process. A kinetic equation for decomposition reaction of 2 was also obtained. The apparent activation energy (Ea) and pre-exponential factor (A) of the main decomposition reaction are 157.70 kJ mol-1 and 1011.97 s-1, respectively. The kinetic equation can thus be expressed as dα/dt = 1011.97(1 - α)e-1.90 x 104/T.
  Guo-Fang Zhang , Yong Wang , Mei-Yu Cai , Da-Min Dai , Ke Yan , An-Shan Ma , Peng Chen , Rui Wang , Ping Li , Jian-Hua Yi , Feng-Qi Zhao , Ji-Zhen Li and Xue-Zhong Fan
  Eight alkaline and alkaline-earth compounds derived from 2,4-dinitroimidazole (2,4-HDNI) were synthesized and characterized by elemental analysis, FT-IR, and TG-DSC, of which K(2,4-DNI) (1), Rb(2,4-DNI)(2,4-HDNI)(H2O)2 (2), and Ba(2,4-DNI)2(H2O)4 (3) were characterized by single-crystal X-ray diffraction analysis. All the three compounds were crystallized from water, but 1 was an anhydrate. The coordination number in 1 and 3 is 10, but in 2 is 9. The 2,4-DNI adopts either η3, η2, or η1 coordination modes depending on the metal cation. In 3, there is an inversion center located on the metal. Only in 2 does water play an important role for the construction of the structure; in 3 it is a hydrogen bonding participant. TG-DSC analyses of 1 were also performed, and non-isothermal decomposition reaction kinetics were obtained.
  Bing Zhou , Junli Liu , Qiuna Wang , Xuan Liu , Xiaorong Li , Ping Li , Qingjun Ma and Cheng Cao
  Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS, an emerging disease characterized by atypical pneumonia. Using a yeast two-hybrid screen with the nucleocapsid (N) protein of SARS-CoV as a bait, the C terminus (amino acids 251 to 422) of the N protein was found to interact with human elongation factor 1-alpha (EF1α), an essential component of the translational machinery with an important role in cytokinesis, promoting the bundling of filamentous actin (F-actin). In vitro and in vivo interaction was then confirmed by immuno-coprecipitation, far-Western blotting, and surface plasmon resonance. It was demonstrated that the N protein of SARS-CoV induces aggregation of EF1α, inhibiting protein translation and cytokinesis by blocking F-actin bundling. Proliferation of human peripheral blood lymphocytes and other human cell lines was significantly inhibited by the infection of recombinant retrovirus expressing SARS-CoV N protein.
  Linxia Zhu , Guogang Zhang , Shengchao Wang , Li Li , Ping Li , Shihua Wu , Xiaoqiu Wang , Lijuan Chen , Chunyuan Pan and Wenzhen Mi
  A new ecdysteroside was isolated from the roots of Lygodium japonicum (Thunb.) Sw. The structure was identified as 2β,3β,14α,20R,22R-pentahydroxy-24R-methyl-5β-cholest-7-en-6-one-3-O-β-D-glucopyranoside by spectral and chemical methods.
  Anne A. Wooldridge , Christopher N. Fortner , Beata Lontay , Takayuki Akimoto , Ronald L. Neppl , Carie Facemire , Michael B. Datto , Ashley Kwon , Everett McCook , Ping Li , Shiliang Wang , Randy J. Thresher , Sara E. Miller , Jean-Claude Perriard , Timothy P. Gavin , Robert C. Hickner , Thomas M. Coffman , Avril V. Somlyo , Zhen Yan and Timothy A. J. Haystead
  In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. Herein we show a role for smoothelin-like protein 1 (SMTNL1), a novel in vivo target of PKG/PKA, in mediating vascular adaptations to exercise. Aortas from smtnl1-/- mice exhibited strikingly enhanced vasorelaxation before exercise, similar in extent to that achieved after endurance training of wild-type littermates. Additionally, contractile responses to α-adrenergic agonists were greatly attenuated. Immunological studies showed SMTNL1 is expressed in smooth muscle and type 2a striated muscle fibers. Consistent with a role in adaptations to exercise, smtnl1-/- mice also exhibited increased type 2a fibers before training and better performance after forced endurance training compared smtnl1+/+ mice. Furthermore, exercise was found to reduce expression of SMTNL1, particularly in female mice. In both muscle types, SMTNL1 is phosphorylated at Ser-301 in response to adrenergic signals. In vitro SMTNL1 suppresses myosin phosphatase activity through a substrate-directed effect, which is relieved by Ser-301 phosphorylation. Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity.
  Ping Li , Shyam S. Chaurasia , Yan Gao , Aprell L. Carr , P. Michael Iuvone and Lei Li
  In zebrafish, the expression of long-wavelength cone (LC) opsin mRNA fluctuated rhythmically between the day and night. In a 24-h period, expression was high in the afternoon and low in the early morning. This pattern of fluctuation persisted in zebrafish that were kept in constant darkness, suggesting an involvement of circadian clocks. Functional expression of Clock, a circadian clock gene that contributes to the central circadian pacemaker, was found to play an important role in maintaining the circadian rhythms of LC opsin mRNA expression. In zebrafish embryos, in which the translation of Clock was inhibited by anti-Clock morpholinos, the circadian rhythms of LC opsin mRNA expression diminished. CLOCK may regulate the circadian rhythms of LC opsin mRNA expression via cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. In control retinas, the concentration of cAMP was high in the early morning and low in the remainder of the day and night. Inhibition of Clock translation abolished the fluctuation in the concentration of cAMP, thereby diminishing the circadian rhythms of opsin mRNA expression. Transient increase of cAMP concentrations in the early morning (i.e. by treating the embryos with 8-bromo-cAMP) restored the circadian rhythms of LC opsin mRNA expression in morpholino-treated embryos. Together, the data suggest that Clock plays important roles in regulating the circadian rhythms in photoreceptor cells.
 
 
 
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