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| Articles
by
Pilanthana Lertsatitthanakorn |
Total Records (
2 ) for
Pilanthana Lertsatitthanakorn |
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Pilanthana Lertsatitthanakorn
and
Bhuddhipong Satayavongthip
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Skin bacterial flora, namely Staphylococcus epidermidis,
are able to metabolise sweat that hence leads to foot odor. Moreover, Bacillus
subtilis was found in the plantar skin of subjects possessing strong foot
odor. The synthetic antibacterial agent generally used in various foot deodorant
formulations is triclosan which tends to cause bacterial tolerance. To avoid
that shortcoming, researchers in this study developed a natural foot deodorant
gel from essential oils. Previous research of our group revealed that cinnamon
oil showed a higher antibacterial activity against S. epidermidis than
the essential oils obtained from kaffir lime, lemongrass, sweet basil, galanga
and ginger. In the present study, the susceptibility of B. subtilis
to the mentioned essential oils was determined and the results showed that cinnamon
oil possessed the highest activity. Foot deodorant gel containing cinnamon oil
was formulated and studied for its biological stability for 90 days at accelerated
conditions. The lethal effect of the cinnamon oil gel exposed to B. subtilis
for 1 h, was studied at day 0, 15, 30, 60 and 90. It was found that on all
sampling days, cinnamon oil gel could decrease by at least 90% the initial bacterial
population after 1 h of contact time. In conclusion, cinnamon oil foot deodorant
gel demonstrated a good ability to decrease the bacteria involved in strong
foot odor. The cinnamon oil foot deodorant gel might be an alternative cosmetic
for people who have strong foot odor. |
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Pawitra Pulbutr
,
Wanida Caichompoo
,
Pilanthana Lertsatitthanakorn
,
Methin Phadungkit
and
Sakulrat Rattanakiat
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The essential oil from the fruits of Amomum uliginosum
K.D. Koenig has been commonly used in Thai herbal formula for the treatment
of gastrointestinal diseases. However, the biological activity of the essential
oil obtained from A. uliginosum fruits has never been reported. This
study was aimed to investigate the pharmacological activities and cytotoxic
effect of the essential oil derived from the fruit of A. uliginosum.
The essential oil derived from the authentic fruits and the commercial fruits
were prepared by distillation with the yield of 2.90±0.00 and 2.90±0.30%
v/w, respectively. The chemical constituents of the essential oil were analyzed
by GC-MS. Twenty one and 13 chemical compounds were found in the essential oil
derived from the authentic and commercial fruits, respectively. The major chemical
compound presented in the essential oil from both sources was bornyl acetate.
The essential oil exhibited an antibacterial activity against gastrointestinal
disorder-related bacteria with the lowest MIC of 75 μL mL-1
against E. coli O157:H7 DMST 12743 and S. aureus DMST 8013. The
essential oil exerted the cytotoxic effect on 3T3 fibroblasts with the IC50
of 0.0725±0.0045 μL mL-1. The strong antimutagenic effect
in Salmonella typhimurium TA 98 was found at the concentration of 3.75
mL plate-1. These results scientifically confirmed the use of the
essential oil derived from A. uliginosum for the medicinal purposes.
Additionally, its potential application for the use as cancer chemoprevention
is also indicated from this study. |
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