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Articles by Peter Robin Hiesinger
Total Records ( 1 ) for Peter Robin Hiesinger
  Wei Zhang , Dong Wang , Elzi Volk , Hugo J. Bellen , Peter Robin Hiesinger and Florante A. Quiocho
  The V<SUB>0</SUB> complex forms the proteolipid pore of a vesicular ATPasethat acidifies vesicles. In addition, an independent functionin membrane fusion has been suggested in vacuolar fusion inyeast and synaptic vesicle exocytosis in fly neurons. Evidencefor a direct role in secretion has also recently been presentedin mouse and worm. The molecular mechanisms of how the V<SUB>0</SUB> componentsmight act or are regulated are largely unknown. Here we reportthe identification and characterization of a calmodulin-bindingsite in the large cytosolic N-terminal region of the <I>Drosophila</I>protein V100, the neuron-specific V<SUB>0</SUB> subunit a1. V100 formsa tight complex with calmodulin in a Ca<SUP>2+</SUP>-dependent manner.Mutations in the calmodulin-binding site in <I>Drosophila</I> leadto a loss of calmodulin recruitment to synapses. Neuronal expressionof a calmodulin-binding deficient V100 uncovers an incompleterescue at low levels and cellular toxicity at high levels. Ourresults suggest a vesicular ATPase V<SUB>0</SUB>-dependent function ofcalmodulin at synapses.
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