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Articles by Peramaiyan Rajendran
Total Records ( 2 ) for Peramaiyan Rajendran
  Peramaiyan Rajendran , Ramachandran Venugopal , Ganapathy Ekambaram , Arumugam Aadithya and Dhanapal Sakthisekaran
  Cancer chemoprevention involves prevention, delay, or reversal of the process of carcinogenesis through ingestion of dietary or pharmaceutical agents. A large number of potential chemopreventive agents are known, some of which have proven effective in clinical trials. These agents may function by a variety of mechanisms, directed at all major stages of carcinogenesis. One mechanism of particular note involves the inhibition of biosynthesis; of polyamines such as spermine, spermidine and putrescine are promising drug for chemoprevention. In the present study we evaluate chemopreventive efficacy of mangiferin against Benzo(a)Pyrene (B(a)P) induced lung carcinogenesis. Male Swiss albino mice strains were selected for the present investigation. Lung carcinoma was induced with B(a) P (50 mg kg-1 body weight, orally) and the treatment was started by the oral administration of mangiferin (100 mg kg-1 body weight). The modulatory effect of the mangiferin was examined on lung and liver to evaluate the level of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation. Mangiferin significantly decreased the levels of polyamines, protein carbonyl, nucleic acid content and lipid peroxidation that were found to be increased in lung cancer bearing animals. Mangiferin could effectively inhibit B(a)P-induced lung carcinogenesis in albino mice by offering protection from protein damage and also by suppressing cell proliferation.
  Ikuo Nishigaki , Balasubramanian Rajkapoor , Peramaiyan Rajendran , Ramachandran Venugopal , Ganapathy Ekambaram , Dhanapal Sakthisekaran and Yutaka Nishigaki
  Consumption of fruits and vegetables has been associated with a low incidence of cardiovascular and other chronic diseases. The present study was aimed at evaluating the protective effects of fresh apple extract (AE) on human umbilical vein endothelial cells (HUVEC) exposed to cytotoxic glycated protein (GFBS)/iron (FeCl3) chelate. The experimental design comprised 10 groups with 5 flasks in each group. Group I was treated with 15% foetal bovine serum (FBS). Groups II, III and IV were treated with GFBS (70 µM), FBS + FeCl3 (20 µM), and GFBS + FeCl3, respectively. The other six groups were as follows: Group V, GFBS + AE (100 µg); Group VI, FBS + FeCl3 + AE (100 µg); Group VII, GFBS + FeCl3 + AE (100 µg); Group VIII, GFBS + AE (250 µg); Group IX, FBS + FeCl3 + AE (250 µg); and Group X, GFBS + FeCl3 + AE (250 µg). After 24 h incubation, cells were collected from all the experimental groups and assessed for lipid peroxidation (LPO) and activities of the antioxidant enzymes cytochrome c reductase and glutathione S-transferase (GST). HUVEC incubated with glycated protein (GFBS) either alone or combined with iron chelate showed a significant (p < 0.001) elevation of LPO accompanied by depletion of superoxide dismutase, catalase, glutathione peroxidase (GPx) and glutathione reductase (GR), in addition to increased microsomal cytochrome c reductase and decreased GST activities. Treatment of GFBS- or GFBS + FeCl3-exposed HUVEC with AE at 100 or 250 µg significantly decreased the level of LPO and returned the levels of antioxidants cytochrome c reductase and GST to near normal in a dose-dependent manner. The extracts recovered viability of HUVEC damaged by GFBS-iron treatment in a concentration-dependent manner. These findings suggest a protective effect of AE on HUVEC against glycated protein/iron chelate-induced toxicity, which suggests that AE could exert a beneficial effect by preventing diabetic angiopathies.
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