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Articles by Pengfei Li
Total Records ( 2 ) for Pengfei Li
  Yue Liu , Congying Fan , Haiyan Hu , Yaowen Yang , Shuning Yan , Yuelan Gu , Meng Ding , Pengfei Li , Yanling Wang , Hongyan Wang and Qie Yang
  Background and Objective: Circulating Tumor Cells (CTCs) are associated with the prognosis of many human cancers. This study aimed to investigate the clinical significance of CTCs in patients with Non-Small Cell Lung Cancer (NSCLC) patients treated with EGFR-TKI. Materials and Methods: This prospective observational study recruited a total of 120 cases of advanced NSCLC patients who were admitted from January, 2018 to July, 2020. All patients received the first-line treatment of EFFG-TKI treatment of gefitinib 250 mg/day or erlotinib 150 mg/day. Patients with Progressive Disease (PD) after 3 months of treatment were regarded as resistant to the treatment. The levels of CTC were measured before treatment and after 3 months of treatment by the Cell Search system. Cancer-related biomarkers CA125, CEA, CA199 and Ki67 were measured using the enzyme-linked immunosorbent assay (ELISA). Results: Deceased patients showed a significantly higher ratio of TNM stage IV and more CTCs compared with the survival cases. A high number of CTCs was positively correlated with CA125, CEA, Ki67 and CA199. In all patients, 161 cases (44.11%) showed resistance to EGFR-TKI treatment. After treatment of 3 months, the CTCs levels and serum CA125 levels were remarkably decreased in non-resistant patients. Patients with CTC≥5 and patients with higher expression of CA125 had markedly shorter 1 year survival. Conclusion: Higher CTCs might be associated with poor clinical outcomes and prognosis and higher CTCs and CA125 levels might predict a higher risk for resistance of EGFR-TKI treatment in NSCLC patients.
  Lingfeng Xue , Pengfei Li , Rongfei Zhang , Xiangshu Piao , Rui Han and Ding Wang
  Fermented potato pulp is a by-product obtained from the potato-starch industry. There could be great economical and environmental advantages if it could be exploited for use as a new feed resource. This study was conducted to evaluate the dietary effect of adding 5% fermented potato pulp to diets fed to lactating sows on sow and litter performance, blood metabolites and hormones. On day 110 of gestation, 80 mixed parity sows (256.0±4.3 kg BW and 3.2±0.2 parity) were moved into a farrowing room and allotted to one of two corn-soybean meal based diets supplemented with either 0 or 5% fermented potato pulp in a completely random design experiment. Each treatment had 40 replicates and the sows were fed the dietary treatments until weaning following 28 days of lactation. Sow lactation weight loss tended to decrease (p = 0.09) and feed intake tended to increase (p = 0.06) when sows were fed fermented potato pulp. The weaning to estrus interval was shorter (p = 0.05) and litter weight gain was also higher (p = 0.03) for sows fed fermented potato pulp. Dietary treatments did not affect plasma glucose, insulin, non-esterified fatty acids, insulin-like growth factor I and follicle-stimulating hormone. Sows fed fermented potato pulp had higher (p = 0.02) plasma urea nitrogen and luteinizing hormone (p = 0.01) than sows fed the control diet. Feeding potato pulp tended to decrease (p = 0.06) creatinine and increase (p = 0.07) estradiol concentrations in sows plasma. These results demonstrate that feeding lactating sows diets containing 5% fermented potato pulp had a positive effect on sow and litter performance.
 
 
 
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