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Articles by Paul K. Lunga
Total Records ( 2 ) for Paul K. Lunga
  Gerald N. Teke , Paul K. Lunga , Hippolyte K. Wabo , Jules-Roger Kuiate and Jean P. Dzoyem
  The stem bark of E. abyssinica is used in traditional medicine for the treatment of diarrhoea in west region of Cameroon. To substantiate this folkloric claim, the methanol extract, fractions and isolated compounds from E. abyssinica stem bark were investigated for their antidiarrhoeal activities in Wistar albino rats. The methanol extract of E. abyssinica stem bark was pre-dissolved in a mixture of methanol and water and partitioned into n-hexane, ethyl acetate and n-butanol fractions. The ethyl acetate portion was fractionated by column chromatography and the structures of isolated compounds elucidated by spectroscopic analyses in conjunction with literature data. Antidiarrhoeal activity was investigated in terms of purging index, consistency of faeces and intestinal transit in castor oil induced diarrhoea, and faecal Shigella load, faecal frequency, variation in bodyweight and blood chemistry in Shigella-induced diarrhoea model in Wistar rats. Two known compounds [(5S,6R,8aR)-5-(carboxymethyl)-3,4,4a,5,6,7,8,8a-octahydro-5,6,8atrimethylnaphthalenecarboxylic acid (1), methyl 3,4,5-trihydroxybenzoate (2) were isolated. The methanol extract, fractions and isolated compounds showed antidiarrhoeal activities evidenced by the reduction in % respondent to diarrhoea, a delay in the period for diarrhoea induction, reduction in purging index and wateriness of faeces. Compounds 1 and 2 inhibited diarrhoeal droppings by 81.01 and 87.34%, respectively. Compared to the methanol extract, fractionation increased the shigellocidal activity with ethyl acetate fraction most active. The experimental findings show that the methanol extract, fractions and isolated compounds from E. abyssinica stem bark possess significant antidiarrhoeal activities justifying the traditional use of this plant in diarrhoeal treatment and may be developed as phytomedicine.
  Paul K. Lunga , Joseph M.M. Nkodo , Jean D. Tamokou , Jules-Roger Kuiate , Donatien Gatsing and Joseph Tchoumboue
  Background and Objective: Paullinia pinnata is an African woody vine whose leaf decoction has been used in Cameroon for the treatment of bacterial infections like typhoid fever, syphilis, gonorrhea, diarrhoea and symptoms such as stomach-ache and waist pain. The present study was designed to evaluate the adverse side effects resulting from the use of P. pinnata methanol leaf extract in the treatment of Salmonella typhimurium-induced typhoid in Wistar rats. Methodology: After the establishment of infection by oral administration of a S. typhimurium suspension, animals were treated by the daily administration of P. pinnata methanol leaf extract at various doses (55.75, 111.50, 223 and 446 mg kg-1 b.wt.). The effect of the extract on body weight evolution was monitored daily. Results: Also, the effect of the extract on relative organ weight, biochemical parameters as well as liver histology was assessed. Irrespective of sex, typhoid fever induced an abnormal increase in the relative weight of most vital organs of toxicological importance. However, extract treatment normalized the excessive increase in relative organ weights; while inducing a significant (p<0.05) body weight gain in a dose-dependent manner. The level of liver enzymes (ALT and AST) were significantly (p<0.05) reduced after the treatment of the animals with P. pinnata leaf extract. The histopathological analysis of the liver revealed that extract treatment greatly reduced the degree of liver affections in a dose-dependent manner. However, at high doses (dose ≥223 mg kg-1 b.wt.) the extract was capable of stimulating hepatic necrosis. Conclusion: The overall results of this study indicate that the methanolic extract of P. pinnata leaves has hepatoprotective effects especially in males. It has adverse side effects at high doses and even at low doses in female rats and thus, should be used with caution in male and should probably be eliminated from the treatment of female subjects.
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