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Articles by Patel Ankita
Total Records ( 1 ) for Patel Ankita
  Gate Suyog , Bandawane Deepti , S. Beautikumari and Patel Ankita
  Background: Rheumatoid Arthritis (RA) is a chronic, relapsing autoimmune disorder. Punica granatum Linn. (Punicaceae) is traditionally used herbal plant, which is reported to have immuno-modulatory and anti-inflammatory activity. In view of its reported activities, present investigation was designed to evaluate anti-arthritic potential of Punica granatum L. leaves in Freund’s Complete Adjuvant (FCA) induced arthritis in laboratory animals along with identification of possible phytoconstituents responsible for the proposed activity. Materials and Methods: Arthritis was induced in experimental animals by subplanter injection of 0.1 mL of FCA (heat killed Mycobacterium tuberculosis in sterile paraffin oil 10 mg mL-1) suspension into the left hind paw. After 14 days of FCA immunization, rats were treated with Punica granatum L. leaves tannin fraction (PGTF) orally at a dose of 50, 100 and 200 mg kg day-1 for 28 days. Indomethacin (2 mg kg-1) was used as a standard. The severity of arthritis was evaluated by symptoms, biochemical, hematological, radiological and histopathological assessment. Results: Therapeutic treatment with PGTF in FCA-induced arthritic rats exhibited significant reduction in serum levels of C-reactive Protein (CRP), Rheumatoid Factor (RF), Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS) and lysosomal enzymes. Furthermore, PGTF treated arthritic rats revealed significant reduction in paw edema formation, arthritic index, Erythrocyte Sedimentation Rate (ESR) and urinary hydroxyproline along with normalization of hematologic changes and body weight. The treatment with PGTF also markedly ameliorated radiologic and histopathologic changes in arthritic joint as compared with arthritic control group. The qualitative, quantitative and HPTLC analysis reveals the presence of gallotannins in PGTF which may be responsible for the proposed activity. Conclusion: The experimental data demonstrates that PGTF potentially ameliorates the symptoms and inhibits the progression of arthritis in experimental animals. The anti-arthritic potential of PGTF can be attributed to its hydrolysable tannin component gallotannin.
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