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Articles by Pasupuleti Visweswara Rao
Total Records ( 4 ) for Pasupuleti Visweswara Rao
  Pasupuleti Visweswara Rao , Elawarasi Krishinasamy , Indireddy Rama Manohar Reddy , Malepati Dhananjaya Naidu and Siew Hua Gan
  Background: Diabetes mellitus is a chronic disease and is one of the main public health concerns worldwide. To date, the potential of many natural products in its treatment are not fully explored. Materials and Methods: In this study, major phytochemicals present in the leaves and stems of Diospyros buxifolia were determined following extraction using distilled water and 70% of methanol. The antidiabetic activities of the extracts were determined in vitro by measuring α-amylase and amyloglucosidase inhibitory activities at four different extract concentrations (0.125, 0.250, 0.500 and 1.000 mg mL–1). Results: Methanolic extracts of D. buxifolia stems found to possess significant α-amylase inhibitory activity (84.68±0.03%) followed by methanolic extract of the leaves (84.00±0.08%), aqueous extracts of the stems (49.44±0.05%) and aqueous extract of the leaves (40.71±0.03%). Methanolic extracts of the stems showed significant inhibition of amyloglucosidase (62.72±0.15%) followed by methanolic extract of the leaves (58.93±0.08%), aqueous extracts of the stems (36.65±0.05%) and finally aqueous extract of the leaves (20.57±0.03%). Conclusion: It can be concluded that methanolic stem extract of D. buxifolia displayed the presence of phytochemicals and also significant α-amylase and amyloglucosidase inhibition. Further analysis needs to be made to find out the mechanism of action of antidiabetic activities of the extracts used in this study.
  Pasupuleti Visweswara Rao
  Nanotechnology is one of the fascinating fields of interest for the researchers due to its swift action and the minimal size product requirement. Recent advancements in the technologies especially into nano-sized particles or materials manufacturing have led to the fabrication of nanomaterial of different sizes and shapes. The advantageous usage of metallic nanoparticles in agricultural ecosystems is not abundantly explored with limited scientific information available. Most of the studies are limited to laboratory conditions and only a few involved with the natural ecosystems. The Nano technological aspects into agricultural and biomedical sciences are found to be thriving in the nearing future. Researchers show much interest in the green synthesis of nanoparticles and beneficial effects in various fields. This mini review concisely describes the nanotechnology advancements in agriculture and biomedical applications which directly or indirectly linked to the human wellness. The scope of the applications of nanotechnology in the fields of agriculture and medicine is vast and yet to know clear understanding of the mechanisms.
  Pasupuleti Visweswara Rao , Kondeti Madhavi and Malepati Dhananjaya Naidu
  Diabetes mellitus is one of the widespread and severe metabolic disorders in humans all over the globe. Various medicinal plants have effectively been used to conquer this global health problem. Rhinacanthus nasutus is widely used in Thai medicine and various parts of the world to treat different diseases i.e., cancers, skin diseases, ringworm etc. The methanolic extract of R. nasutus was administered to streptozotocin induced (50 mg kg-1 b.wt.) diabetic male albino wistar rats for 30 days to identify its effect on serum and hepatic cholesterol levels. Oral administration of R.nasutus (200 mg kg-1 b.wt.) significantly decreased the serum total cholesterol, triglycerides, LDL-cholesterol and increased the HDL-cholesterol levels. The hepatic total cholesterol, triglycerides, phospholipids were also decreased after administration of R. nasutus in diabetic rats. The results of this experimental study indicate that R. nasutus possesses hypolipidemic activity without evident toxic effects to the experimental animal.
  Indireddy Rama Manohar Reddy , Pasupuleti Visweswara Rao , Bobbu Pushpa Latha and Tartte Vijaya
  Background and Objectives: The present study was aimed to investigate the protective effect of saponin-rich aqueous leaf extract of Gymnema sylvestre (SGE) on obesity and oxidative stress in rats fed with cafeteria (CA) and high-fat (HF) diets. Methodology: Male Wistar rats were fed CA and HF diets for 8 weeks to induce obesity and oxidative stress. The SGE (100 mg kg-1) was administered orally to CA and HF fed rats for 8 weeks. Changes in body weight gain, food consumption, fat storage, serum parameters, fecal lipid excretion and liver oxidative stress parameters were measured. Results: SGE showed protective effect on body weight gain, food consumption and visceral fat accumulation. The SGE treatment elicited a significant reduction in serum levels of glucose, atherogenic index, total cholesterol, triglycerides, Low-Density Lipoproteins-Cholesterol (LDL-C), Very Low Density Lipoproteins-Cholesterol (VLDL-C) and while High-Density Lipoproteins-Cholesterol (HDL-C) level increased. Furthermore, SGE treatment decreased the liver lipids, lipid peroxidation and increased antioxidant levels and fecal lipid excretion in obese rats. Conclusion: In conclusion, intake of SGE may be a feasible therapeutic strategy for prevention of cafeteria and high-fat diet- induced obesity and oxidative stress.
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