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Articles by Pascal D.D. Chuisseu
Total Records ( 2 ) for Pascal D.D. Chuisseu
  Paul F. Moundipa , Silvere Ngouela , Georges Alain Tchamba , Nico F. Njayou , Pascal D.D. Chuisseu , Fabien Zelefack and Etienne Tsamo
  The antihepatotoxic effects of Xylopia phloiodora extracts were evaluated in experimental models of liver injury in rats induced by CCl4 or paracetamol. Crude extract (CE), ether extract (EE) and essential oils from stem bark or leaves were tested. Hepatic function was accessed by measuring serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in rats. Liver malondialdehyde (MDA) and reduced glutathione were also measured in control and treated rats. X. phloiodora leaves (CE) and stem bark (CE) extracts showed hepatoprotective activities at doses equivalent to 2.5 g of plant/kg, since serum levels of ALT and AST in rats given the extracts were significantly low (p<0.05 and p<0.01, respectively) when compared to control CCl4-injured rats. Further studies were carried on the CE from stem bark of X. phloiodora which showed the highest level of protection against hepatitis. Further studies of the crude extract showed highest antihepatotoxic activity with the ether precipitate (PE) which was effective at 100mg/kg for hepatocurative activity in CCl4-injured rats. In experiments comparing the PE (100 mg kg-1) to a reference antihepatotoxic substance (silymarin) the PE exhibited a 71 and 80% hepatoprotection compared to the 80 and 90% one exhibited by silymarin in CCl4-and paracetamol-injured rats respectively. This study demonstrated that ether precipitate of Xylopia phloiodora was effective in protecting the liver from toxic hepatitis.
  Hubert J. Donfack , Rodrigue T. Kengap , B. Ngameni , Pascal D.D. Chuisseu , Angele N. Tchana , Daniela Buonocore , Bonaventure T. Ngadjui , Paul F. Moundipa and Fulvio Marzatico
  Abstract: Background: Degenerative diseases in general and toxic hepatitis in particular remains a serious public health problem. The in vitro hepatoprotective effect of the crude extract and isolated compounds from Ficus cordata Thunb (Moraceae) on the CCl4-induced liver cell damage as well as the possible antioxidant mechanisms involved in this protective effect, were investigated. The hepatoprotective activity of these compounds was tested in vitro against CCl4-induced damage in rat hepatoma cells. In addition, radical scavenging activity, β-Carotene-Linoleic Acid Model System, Ferric-Reducing Antioxidant Parameter and microsomal lipid peroxidation assays were used to measure antioxidant activity of crude extract and isolated compounds. Silymarin and trolox were used as standard references and respectively exhibited significant hepatoprotective and antioxydant activities. Results: The phytochemical investigation of this crude extract led to the isolation of five compounds identified as: β-amyrin acetate (1), Lupeol (2), Catechin (3), Epiafzelechin (4), Stigmasterol (5). These compounds showed significant hepatoprotective activities as indicated by their ability to prevent liver cell death and LDH leakage during CCl4 intoxication. Conclusion: These results suggest that the protective effects of the crude extract of Ficus cordata against the CCl4-induced hepatotoxicity possibly involve the antioxidant effect of some of these compounds.
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