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Articles by Parvin Zareian
Total Records ( 2 ) for Parvin Zareian
  Parvin Zareian , Abdolreza Sotoodeh Jahromi , Fateme Hemati Rad and Safar Zarei
  Problem statement: The purpose of this study was to evaluate the role of resistin and Tumor Necrosis Factor-α (TNF-α) in insulin resistance during pregnancy. Approach: Serum resistin and TNF-α concentrations were measured by ELISA in 86 healthy pregnant women (26, 23 and 37 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 21 healthy non pregnant women in a cross sectional study. Results: Resistin concentration was significantly higher in the third trimester (9.5±3.3 ng mL-1) as compared with non pregnant women (7±3.3 ng mL-1). Serum TNF-α level were also significantly increase in pregnant women (2.6±1.9 pg mL-1) as compared with maternal healthy controls (0.8 ±0.7 pg mL-1). There were significant correlation between gestational age and BMI (r = 0.28, p = 0.01), resistin (r = 0.36, p = 0.002) and TNF-α (r = -0.44, p<0.0001). There was not significant correlation between gestational age and Insulin Resistance (IR). We also did not found correlation between IR and resistin as well as between IR and TNF-α in pregnant women. Conclusion: TNF-α and resistin do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.
  Abdolreza Sotoodeh Jahromi , Parvin Zareian and Abdolhossein Madani
  The purpose of this study was to evaluate the role of Interleukin-1β (IL-1β) in Insulin Resistance (IR) during normal pregnancy. This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-1β and resistin concentrations were measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, (Homeostasis Model Assessment) HOMA-IR. Serum resistin concentration was found to be significantly raised in the second and third trimester as compared with women with first trimester of pregnancy but it was not found any statistical difference in serum resistin concentration between the healthy controls and pregnant women. There was no difference in IL-1β level between pregnant 1.32±0.48 ng mL-1 and non pregnant women 1.44±0.49 ng mL-1. IL-1β level were significantly decreased with increase in gestational age. Pregnant women exhibited higher score of HOMA-IR 2.1±0.9 compared non pregnant women 1.7±0.4 but there were not difference in this score between pregnant subjects in different gestational age. There was not any correlation between maternal gestational age and serum level of IL-1β. The findings of this study suggest that IL-1β do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.
 
 
 
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