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Articles by Paras Sharma
Total Records ( 3 ) for Paras Sharma
  Hardeep Singh Gujral , Mamta Angurala , Paras Sharma and Jaspreet Singh
  Five commonly consumed pulses, Mah (Vigna mungo), Green mung (Vigna radiata), Arhar (Cajanas cajan), Masur (Lens esculantus), and Moth (Vigna aconitifolia), were studied for their total phenolic content and antioxidant activity after germination (12 and 24 h) and pressure cooking. Arhar had the highest total phenolic content (6.71 mg ferulic acid/g flour) whereas Moth had the least (1.54 mg/g). All pulses, except Moth, showed a significant decrease in total phenolic content after germination. The antioxidant activity of the pulses varied from 10.61 to 36.38% (DPPH radical scavenging activity), which significantly decreased with germination in all pulses except Moth. The total phenolic content highly correlated with the antioxidant activity in the pulses. Cooking lowered the total phenolic content by 10−45% and antioxidant activity by 27−68% in the control and germinated pulses.
  Hardeep Singh Gujral , Paras Sharma , Arvind Kumar and Baljeet Singh
  Three paddy cultivars varying in l/b ratio (2.67−4.59) were dehusked to obtain brown rice. The brown rice was germinated for 24 and 48 h, dried, and milled into grit. The grit from controlled (un-germinated) and germinated brown rice was extruded at 100 and 120°C and the total phenolic content and antioxidant activity of the extrudates was determined. The total phenolic content of the control and germinated brown rice varied from 0.803−0.992 mg/g ferulic acid equivalent and germination increased total phenolic content by 8.8−12.0%. The antioxidant activity varied from 6.96−15.86% (decrease in absorbance of 2,2-diphenyl-1-picrylhydrazyl) and germination increased the antioxidant activity by 18.2−37.2%. Upon extrusion at 100°C, the total phenolic content decreased by over 50%. A further decrease of 6−15% in total phenolic content was observed when the extrusion temperature was increased from 100 to 120°C. Similar decrease in the antioxidant activity was observed upon extrusion and rise in extrusion temperature. Significant increase in water solubility, water absorption capacity, and percent expansion of extrudates was observed upon extrusion. The extrudates from germinated brown rice were used to make an instant pudding, which upon evaluation scored higher as compared to the pudding from control brown rice.
  Rohit Sahu , Goli Divakar , Kalyani Divakar and Paras Sharma
  Gmelina arborea roxb commonly known as ‘Gambhari’ tree, the various parts of the plants are widely used in diarrhoea, anti-pyretic, thirst, anemia, leprosy, ulcers, consumption, strangury and vaginal discharges. We tested the cytotoxic potential of Gmelina arborea roxb in HL-60 cells. Aqueous Extract of Gmelina arborea roxb (AEGA) was tested at the various concentrations 5, 10, 15 and 20 mg in MTT assay, Cell Viability assays and clonogenic assay. Our study shows that AEGA inhibits cell growth and decrease the cell viability. The AEGA inhibits cell proliferation at a dose and time dependent manners measured by MTT assay. The AEGA very significantly decreased the cell viability of HL-60 Cells after 24 and 48 h compared to the control cells. In the semisolid culture, the number of colonies decreased significantly (p<0.01) in a dose-dependent manner. Overall, AEGA has shown a substantial and significant anti cancer activity in all the models. This protective effect might have been mediated by apoptosis mechanisms.
 
 
 
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