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Articles by Paramaguru Rathinavelusamy
Total Records ( 1 ) for Paramaguru Rathinavelusamy
  Papiya Mitra Mazumder , Vivek Agarwal , Dinakar Sasmal and Paramaguru Rathinavelusamy
  Background: This study evaluated the acute and sub-chronic diuretic, saliuretic and kaliuretic effects of orally administered Methanol Extract of Barleria lupulina (MEBL) leaves in normal rats and thereby, confirm its ethno medical use. Materials and methods: Acute diuretic activity was estimated by single dose methanol extract of leaves of Barleria lupulina (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.), duration of the study is 24 h. Sub-chronic diuretic activity was estimated by administered extract (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.) for the period of eight days. Results: In acute study, the diuretic effect of MEBL at the higher dose i.e. 400 mg kg-1b.wt. was found to be highly significant at 1, 2, 4 and 6 h (p<0.01 vs. control). Both the doses of plant extract significantly enhanced the excretion of the Na+ and K+ versus control (p<0.01). In Sub-chronic study, both the doses of MEBL produced significant diuresis until day 3 (MEBL 200 mg kg-1 b.wt.) and day 5 (MEBL 400 mg kg-1 b.wt.). MEBL 400 mg kg-1 b.wt. increased the excretion of Na+ and K+ significantly (p<0.01 vs. control) throughout the treatment from Day 1 to 8. Conclusion: The present study confirmed the ethno pharmacological use of Barleria lupulina as a diuretic agent based up on the experimental conditions tested.
 
 
 
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