Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Papiya Mitra Mazumder
Total Records ( 7 ) for Papiya Mitra Mazumder
  S. Arulmozhi , Papiya Mitra Mazumder , L. Sathiyanarayanan and Prasad A. Thakurdesai
  Background: The analgesic and anti-inflammatory effect of ethanolic extract of leaves of Alstonia scholaris Linn. (Apocynaceae) has been reported earlier. The objective of this study was to investigate analgesic and anti-inflammatory effect of the fraction which is responsible for the activity. Materials and Methods: The Dichlormethane (DCM) and Ethylacetate Fractions (EA) from ethanolic extract of leaves of Alstonia scholaris Linn. were subjected to analgesic, anti-inflammatory activity using hot plate, acetic acid induced writhing and carrageenan induced inflammatory models. The ulcerogenicity of the fractions was also tested using pylorus ligation model. Results: There was a significant (p<0.01) decrease in the writhing and decrease (p<0.01) in the paw volume in carrageenan induced inflammation with DCM fraction, whereas there was no effect in basal reaction time in hot plate method. There was a significant (p<0.01) decrease in the number of wriths with EA whereas there was no effect in basal reaction time and paw volume with EA fraction. Conclusion: The results obtained indicate that DCM has peripheral analgesic activity, anti-inflammatory activity and lack ulcerogenecity, whereas EA did not possess analgesic and anti-inflammatory activities. This confirms that the DCM fraction consist of components responsible for the analgesic and anti-inflammatory activities of Alstonia scholaris Linn.
  A. Balasubramaniam , R. Manivannan , R. Paramaguru , Papiya Mitra Mazumder and M. Vijayakumar
  Background: This study was designed to investigate the anti-inflammatory and free radical scavenging potential of 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam. Materals and Methods: The anti-inflammatory activity of 100, 200, 400 mg kg-1 of 50% ethanolic extract of stem bark of Toddalia asiatica was assessed by Carrageenan-induced rat paw edema method and Cotton pellet granuloma method. The antioxidant activity of the same was assessed by Free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), Nitric oxide scavenging activity, Hydroxyl radical scavenging activity and Chelation of Ferrous (Fe2+) ions. Results: All the three doses (100, 200, 400 mg kg-1) of the extract showed reduction in paw volume from first hour to third hour significantly. The extract at a dose of 400 mg kg-1 p.o. of the extract showed the maximum value 44.37% of anti-inflammatory activity. The 100, 200, 400 mg kg-1 p.o. of the extract significantly (p<0.01) reduced the granuloma dry weight when compared to the control. Toddalia asiatica showed good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH with IC50 value of 240.07 μg mL-1, OH radical with IC50 value of 432.17 μg mL-1, NO radical with IC50 value of 324.81 μg mL-1 and the same showed moderate scavenging activity against Chelation of Fe2+ ions with IC50 value of 483.21 μg mL-1. Conclusion: Present study indicates that 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam possessed effective anti inflammatory and antioxidant activity.
  Papiya Mitra Mazumder , D. Sasmal , S. Arulmozhi , Ankita and P. Mahesh Kumar
  Background: Salvia splendens and Pterospermum acerifolium (L.) Willd are two different plant species widely available in Jharkhand region. Literature review and phytochemical investigations prompted the possible antioxidant property of these plants. Materials and methods: The plant materials were collected, shade dried and individually subjected to extraction with methanol. The methanolic extract of Salvia splendens (MESS) and Pterospermum acerifolium (MEPA) were subjected to various in vitro antioxidant tests-DPPH radical scavenging activity, scavenging of hydrogen peroxide and superoxide anion scavenging activity. Results: There was a significant decrease in the DPPH radical, hydrogen peroxide and superoxide anion in various concentrations tested. The results observed were comparable to that of standards l- ascorbic acid and BHA. However, MESS had similar but quantitatively lesser activity than MEPA. The observed antioxidant activity is attributed to the phytoconstituents terpenoids, anthocyanins in Salvia splendens and flavonoid, kaempferol and luteolin in Pterospermum acerifolium.
  S. Arulmozhi , Papiya Mitra Mazumder , L. Sathiyanarayanan and Prasad A. Thakurdesai
  Background: The antianxiety activity of the ethanolic extract of leaves of Alstonia scholaris (Family: Apocynaceae) has been well established. The objective of the present study is to evaluate the anti-anxiety activity of the ethyl acetate fraction from ethanolic extract of leaves of Alstonia scholaris. Material and method: EA fraction from Alstonia scholaris was tested against various anti-anxiety models viz. elevated plus maze, open field, hole board, light dark, mirror chamber and foot shock induced aggression models. The change in brain monoamines was estimated. The possible serotonergic effect was tested by 5-Hydroxy Trypto Phan (5-HTP) induced ‘wet dog shake’, tail suspension and modified forced swim tests. Result: EA was found to be significantly active in open filed test, foot shock induced aggression and mirror chamber models of anxiety. However, lack of activity in elevated plus maze, light dark box, hole board test models, decrease in spontaneous motor activity, potentiation of 5-HTP, increase in 5-hydroxy tryptamine in brain indicate EA to have serotonergic effects. Decrease in immobility time in tail suspension test which was inhibited by reserpine and increase in swimming behaviour in forced swim test were conclusive evidence of selective serotonin reuptake inhibition. Conclusion: The present study suggest that EA possess antianxiety and antidepressant activity. The apparent mechanism of action is selective serotonin re-uptake inhibition.
  Papiya Mitra Mazumder , Rathinavelusamy Paramaguru , Anuradha Mohanty and Dinakar Sasmal
  Background: Barleria lupulina is well recognized traditional medicine in the treatment of diabetes mellitus but no scientific data has been reported to its ethnomedical use in eye related long term complications of diabetes. Objective of the present study is to evaluate the anti-cataract activity of leaves of Barleria lupulina Lindl. along with its aldose reductase potential. Materials and Methods: Methanol extract of Barleria lupulina Lindl. (MEBL) was successively fractionate with hexane (HFBL), ethyl acetate (EFBL) and the aqueous fraction (AFBL). All the fractions and methanol extract were subjected to qualitative and quantitative phytochemical screening. In vitro antioxidant activity of the same was assessed by free radical scavenging activity using DPPH and hydrogen peroxide assay. The active ethylacetate fraction (EFBL) was further subjected to in vitro anti cataract evaluation against glucose induced cataractogenesis by using goat lenses. Results: The lenses incubated with EFBL at 200 and 400 μg mL-1 concentration seemed to retard the progression of lens opacification and showed a significant restoration of glutathione, SOD level (p<0.01) and reduced the level of TBARS (p<0.01) when compared with positive control group (glucose 55 mM). EFBL showed promising percentage inhibition of aldose reductase activity with lower IC50 value (50.118 μg mL-1). Conclusion: Hence, this study demonstrated that the EFBL possess significant anticataract, antioxidant and aldose reductase inhibition properties.
  Priya Ranjan , Papiya Mitra Mazumder , R. Parmaguru , Dinakar Sasmal , Rakesh Kumar Sinha , Yogender Aggarwal and Joyani Das
  Background and Objective: Salvia species have been used since ancient times for more than 60 different ailments. Salvia splendens shows a wide availability in Jharkh and region. According to existing literature, its hypoglycemic activity has already been established in diabetic-rodent model. Therefore, an effort has been made to further explore the efficacy of the active fraction of the plant against diabetes and diabetic neuropathy. Materials and Methods: The plant material was collected, shade dried and extracted with methanol. Ethyl acetate fraction of the methanolic extract (SSEA) was subjected to various tests for neuropathic pain assessment (Tail flick, Cold allodynia, R and all Selitto), biochemical tests (fasting blood glucose level, lipid peroxidation, reduced glutathione, catalase levels in brain), Motor Nerve Conduction Velocity (MNCV) determination and histopathological evaluation of the sciatic nerve. Results and Conclusion: There was a significant decrease in blood glucose level in animals treated with SSEA. At a dose of 400 mg kg-1, SSEA showed reduction of MDA and increase in SH and catalase levels in brain. The MNCV in diabetic rats (STZ-NA induced) treated with SSEA 200 and 400 mg kg-1 showed somewhat elevation in nerve conduction velocity as compared to that of diabetic rats. Transverse section of sciatic nerve showed changes due to diabetic nephropathy such as axonal swelling, derangement of nerve fibres which were reverted by 400 mg kg-1 of SSEA.
  Papiya Mitra Mazumder , Vivek Agarwal , Dinakar Sasmal and Paramaguru Rathinavelusamy
  Background: This study evaluated the acute and sub-chronic diuretic, saliuretic and kaliuretic effects of orally administered Methanol Extract of Barleria lupulina (MEBL) leaves in normal rats and thereby, confirm its ethno medical use. Materials and methods: Acute diuretic activity was estimated by single dose methanol extract of leaves of Barleria lupulina (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.), duration of the study is 24 h. Sub-chronic diuretic activity was estimated by administered extract (200 and 400 mg kg-1 b.wt. p.o.) and furosemide (10 mg kg-1 b.wt. p.o.) for the period of eight days. Results: In acute study, the diuretic effect of MEBL at the higher dose i.e. 400 mg kg-1b.wt. was found to be highly significant at 1, 2, 4 and 6 h (p<0.01 vs. control). Both the doses of plant extract significantly enhanced the excretion of the Na+ and K+ versus control (p<0.01). In Sub-chronic study, both the doses of MEBL produced significant diuresis until day 3 (MEBL 200 mg kg-1 b.wt.) and day 5 (MEBL 400 mg kg-1 b.wt.). MEBL 400 mg kg-1 b.wt. increased the excretion of Na+ and K+ significantly (p<0.01 vs. control) throughout the treatment from Day 1 to 8. Conclusion: The present study confirmed the ethno pharmacological use of Barleria lupulina as a diuretic agent based up on the experimental conditions tested.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility