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Articles by Pamhidzai Dzomba
Total Records ( 2 ) for Pamhidzai Dzomba
  Pamhidzai Dzomba and Estele Mwanza
  Background and Objective: Ceratotheca sesamoides, Corchorus fascicularis, Corchorus olitorius and Abelmoschus esculentus are edible bush okras used to manage diabetes mellitus type 2 in traditional practices worldwide. In this study we investigate the alpha-glucosidase and dipeptidyl peptidase inhibitory activity of the four bush okras’ leaf, seeds and pods extracts. Materials and Methods: Liquid-liquid extraction was used for extracting the active phytochemicals. The extracts and standard inhibitors, sitagliptin and precose were then used in in vitro studies to determine percentage inhibition and IC50 values using UV-VIS spectrophotometry. Results: The C. sesamoides, C. fascicularis, C. olitorius and A. esculentus ethanolic extracts showed significant dipeptidyl peptidase inhibitory activity with IC50 values ranging from 1.53-92.32 μg mL1 and α-glucosidase inhibitory activity with IC50 values ranging from 1.85-8.43 μg mL1. Most of the extracts showed greater than 50% inhibition at concentration lower than 10 μg mL1. Leaf and seed extracts showed the best results with IC50 values lower than those of standard inhibitors, 2.32 and 2.38 μg mL1 for sitagliptin and precose, respectively. Among the okras A. esculentus showed the best results, IC50 values<2 μg mL1. Conclusion: Results of the present studies show that administration of polar extracts i.e., aqueous infusions of C. sesamoides, C. fascicularis, C. olitorius and A. esculentus inhibits the enzymes, α-glucosidase and dipeptidyl peptidase. Thus the study supports the global use of the edible okra species in traditional medicine to manage diabetes mellitus type 2.
  Hardlife Rambwawasvika , Pamhidzai Dzomba and Luke Gwatidzo
  Background and Objectives: Drug resistance causes fungal infections such as dandruff, athlete`s foot and ring worm to become difficult to treat. The study was undertaken to investigate the antifungal activity and phytochemical composition of Dicerocaryum senecioides extracts as an alternative remedy in primary health care. Materials and Methods: Agar well diffusion test were used to assess the antifungal activity. Thin Layer Chromatography (TLC) was used to screen for the phytochemical composition of the crude extracts by visualizing the developed plates under the Ultra Violet light and staining with standard revealing agents. Results: Ethyl acetate extract showed the highest antifungal activity followed by dichloromethane, ethanol, aqueous and hexane extracts in respective order of decreasing activity. The Minimum Inhibition Concentrations (MIC) of ethyl acetate were 1.25, 2.50, 1.25 and 5.00 mg mL1 while those for dichloromethane extract were 2.50, 1.25, 0.625 and 2.50 mg mL1 for fungi strains Aspergillus flavus, Aspergillus niger, Fusarium oxisporum and Penicillium italicum, respectively. The TLC phytochemical profile of the ethyl acetate extract revealed the presence of 8 compounds while dichloromethane extract revealed 5 compounds. The phytocompounds observed include tannins, phenolics, flavonoids, carbohydrates, glycosides, saponins, alkaloids, terpenes and steroids. Conclusion: The present study shows that Dicerocaryum senecioides moderately polar and polar extracts consist of remarkable antifungal activity and significant amount of health benefiting phytocompounds therefore it is a good candidate for searching for lead compounds to develop new antifungal therapies to deal with drug resistant fungal strains.
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