Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by P.R.C. Esegbue-Peters
Total Records ( 2 ) for P.R.C. Esegbue-Peters
  Y. Raji , A.O. Morakinyo , O.S. Akinsomisoye , A.K. Oloyo , P.R.C. Esegbue-Peters and Olufadekemi T. Kunle-Alabi
  This study was carried out to investigate the impact of oral administration of chloroform extract of Carica papaya seed (CPE) on implantation and pregnancy in female albino rats. The study was divided into three experimental sections. Each section was subdivided into 4 groups treated, respectively with 25, 50 and 100 mg kg 1 b.w CPE and 2.5% tween 80 in normal saline (vehicle for CPE; control). Rats in section 1 were treated with CPE for two weeks before mating (pre-coital). Rats in section 2 were administered CPE from day 1 of pregnancy till term (post coital) while rats in section 3 received the extract for two weeks before mating and thereafter throughout term (pre and post-coital). Implantation sites and resorptions were determined in some of the pregnant rats after laparotomy. The gestation period, litter size and fetal weight were recorded in the remaining rats. The litters were also observed for any morphological alterations. The extract treated rats had significant decreases in litter size and implantation count (p<0.01). The percentage resorptions increased in a dose dependent manner while the fetal weight and morphology remain unchanged when compared with the normal untreated control groups. The percentage resorptions were high in CPE treated rats when compared with the control group. None of the 100 mg kg 1 b.w CPE treated female rats had litters. The results suggest that the chloroform extract of Carica papaya seed has anti-implantation and abortifacient properties in female albino rats.

  Y. Raji , A.O. Morakinyo , A.K. Oloyo , O.S. Akinsomisoye , Olufadekemi , T. Kunle-Alabi , P.R.C. Esegbue-Peters and F.O. Awobajo
  The impact of oral administration of 100 mg kg 1 b.w of chloroform extract of Carica papaya seed (CPE) on oestrous cycle, fertility and serum 17 -oestradiol levels, in female rats was investigated. Ten proestrous rats received 2.5% tween 80 in normal saline (vehicle for CPE) and served as the control in each part of the study. In the oestrous cycle study, ten proestrous rats were treated with CPE for 14 days. The phases and frequencies of the oestrous cycles of the rats were determined daily for another 14 days while CPE treatment continued. In the fertility study, ten proestrous rats were treated as in the oestrous cycle study for 14 days and were thereafter cohabited with fertile untreated male rats for another 14 days while CPE treatment lasted. CPE did not adversely affect body weight of the rats. However there was a significant decrease (p<0.05) in the weight of the ovary, but not in the uterus. There was a significant decrease (p<0.01) in serum 17 -oestradiol levels in CPE treated rats. The oestrous cycle became irregular, with prolonged diestrous phase from the 3rd week of CPE treatment. There were disorganization and degeneration in the ovary. The uterus showed signs of vacuolation and mild disorganization. The extract treated rats produced a significant decrease in litter number (p<0.01) but the fetal weight and morphology remain unchanged relative to the control. The results suggest that chloroform extract of Carica papaya seed has antifertility properties, possibly acting via inhibition of oestrogen secretion.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility