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Articles by P.N. Ibuzo
Total Records ( 2 ) for P.N. Ibuzo
  O.E. Yakubu , E. Ojogbane , V.O. Nwaneri-Chidozie , P.N. Ibuzo , Ale, E. M. and S.S. Awudu
  Background and Objective: Diethylnitrosamine (DEN) is a hepatotoxic compound found in many foods and drugs capable of causing liver cancer. This study was undertaken in order t o investigate the hepatoprotective efficacy of the ethanolic extract of the leaf of Ficus sur on liver damage induced by DEN. Materials and Methods: Twenty Albino Wistar rats were divided into 4 groups, group A served as the normal control group, received water, group B received 200 mg kg1 DEN once, group C received 200 mg kg1 ethanolic extract of Ficus sur along with DEN and group D received 200 mg kg1 silymarin as reference standard along with DEN. The experiment lasted for 2 weeks after which the animals were sacrificed and the blood collected for biochemical analyses. Results: Administration of DEN caused a significant (p<0.05) increase in the activities of AST and ALT as well as the concentration of total and direct bilirubin, while the levels of albumin and total protein were markedly (p<0.05) reduced. However, treatment with Ficus sur extract ameliorated the levels of these biomarkers in the experimental group. The effect elicited by the extract was not statistically different (p<0.05) when compared to silymarin, a standard drug. Conclusion: The ethanolic extract of Ficus sur protects against DEN-induced hepatotoxicity on Wistar rats and can play a crucial role in the development of modern hepatoprotective drug.
  O.E. Yakubu , V.O. Nwaneri-Chidozie , P.N. Ibuzo , R.E. Yohanna and O.M. Aledu
  Background and Objective: Blood disorders are frightful diseases because the patient suffers pain, disfigurement and loss of many physiological processes. In this study, the effects of ethanol extracts of Senna occidentalis leaves on haematological parameters in diethyl nitrosamine-induced toxicity was analyzed. Materials and Methods: In the experiment, 24 Wistar albino rats were divided into 4 groups of 6 rats each and toxicity was induced intraperitoneally by using diethyl nitrosamine (DEN) at 200 mg kg1. Group one served as the normal control, group two was administered DEN only. Group three was administered DEN and ethanolic extract at 200 mg kg1. Group four was administered DEN and silymarin (5 mg kg1). The rats were sacrificed after 3 weeks of treatment. Blood samples were collected through cardiac puncture and used for hematological analysis; Red Blood Cell (RBC), White Blood Cell (WBC), platelets (PLT), procalcitonin test (PCT), Mean Platelet Volume (MPV), Platelet Distribution Width count (PDWc), haematocrit (HCT), Mean Cell Volume (MCV), Mean Cell Haemoglobin (MCH), Mean Cell Haemoglobin Count (MCHC) and red blood distribution width count (RDWc). Results: The DEN administration caused a significant increase (p<0.05) in RBC and HGB compared to the normal control and a significant decrease in PLT levels, whereas the concentrations of WBC, MID and GRA and LYM decreased significantly (p<0.05). Administration of ethanolic extracts/silymarin significantly (p<0.05) moderated the hematological indices. Conclusion: Due to its ability to moderate levels of haematological parameters, it is therefore, recommended for household management of blood related anomalies.
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