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Articles by P.K. Das
Total Records ( 2 ) for P.K. Das
  S. Maity , A. Ukil , J.R. Vedasiromoni and P.K. Das
  The present study was conducted to investigate the absorption, distribution and pharmacokinetics of TFDG in mice for which it was labeled with 125I. For comparison, the radiolabeled polyphenol was given either along with Black Tea Extract (BTE) or as pure TFDG. Following intravenous (5 mg kg-1) or intragastric (500 mg kg-1) administration, plasma and tissue levels were quantified by radioactive counting and the results were analysed by the SPSS program. Although lower than intravenous dosing, maximum plasma concentration (Cmax) for TFDG was achieved at 6 h post-oral dosing with an AUC0-∝ of 504.92 g min L-1, which was 20 fold higher than that for i.v. dosing. Maximum radioactivity (42%) was recovered in kidney following i.v., administration, whereas for oral administration maximum radioactivity (0.07%) was recovered in liver as revealed by tissue distribution studies. Uptake of TFDG was > 4-fold more efficient in hepatocytes than in non parenchymal cells. However, TFDG showed better absorption by various organs as well as by liver cells when given along with BTE. Moreover, a second equal administration of TFDG after 6 h interval enhanced tissue levels of radioactivity above those after a single administration. These results point towards a wide distribution of 125I-TFDG in mouse organs and suggest that frequent consumption of black tea may be better for increased systemic availability of polyphenols.
  P.K. Das , S.Z. Ali , A.B.M.M. Islam and B.K. Roy
  The study was conducted at Baghabarighat milk pocket area to observe the productive and reproductive performance of the crossbred of Sahiwal x Friesian, Sahiwal x Pabna, Friesian x Pabna and Pabna x Pabna during the period from 1990 to 1998. Comprising four genetic groups data of 41 Sahiwal x Friesian, 72 Sahiwal x Pabna, 55 Friesian x Pabna and 18 Pabna x Pabna were considered to evaluate birth weight of calves, age at puberty, gestation length, service per conception, post partum heat period, lactation length, and daily milk yield. Five Sahiwal and four Friesian sires were used for the crossbreeding. The exotic sire effect of individuals on their daughters were also evaluated in this study. Statistical analysis of the results showed that the genetic group had a significant effect on birth weight (P<0.001), age at puberty (P<0.001), post partum heat period (P<0.01), lactation length (P<0.01) and daily milk yield (P<0.001). But genetic group had no significant effect on gestation length and number of services per conception. The performance of SL x F cows with regard to birth weight of calves (26.35±0.35 kg), age at puberty (25.21±0.55 months), lactation length (260.38±4.48 days) and daily milk yield (10.56±0.14 litres), was found to be better among the other genetic groups. The best performance for the trait service per conception (1.29±0.13) and post partum heat period (104.82±6.53 days) was observed in Pabna x Pabna cows. F x Pabna grades had a slightly shorter gestation length (280.59±0.91 days) than the other genetic groups. So it can be concluded that SL x F crossbred are well ahead to other genetic groups in respect of productive aspect, whereas F x Pabna crosses show the remarkable performance both for production and reproduction. Under this consideration the F x Pabna grades ranked first in over all merit followed by SL x F, SL x Pabna and then Pabna x Pabna cows. Individual sire effect was found significant on birth weight (P<0.05) and average daily milk yield (P<0.05) in SL x F genetic group, on birth weight (P<0.05), age at puberty (P<0.05) and lactation length (P<0.05) in SL x Pabna genetic group and on lactation length (P<0.05) and average daily milk yield (P<0.05) in F x Pabna genetic group. The pooled estimates of heritability for birth weight, age at puberty, gestation length, service per conception, post partum heat period, lactation length and daily milk yield were 0.44±0.30, 0.14±0.17, 0.25±0.21, 0.03±0.12, 0.33±0.26, 0.46±0.33 and 0.43±0.27 respectively. In this study the h2 estimates of reproductive traits were found lower than that of productive traits which indicate that these traits are mostly influenced by managemental factors rather than genetic variability.
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