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Articles by P.E. Ebong
Total Records ( 7 ) for P.E. Ebong
  C.E. Fischer , V.A. Fischer , M.I. Akpaso , O.O. Effiom-Ekaha and P.E. Ebong
  Background and Objective: Lophira lanceolata and Alchornea cordifolia are plants used for the treatment and management of perimenopausal, menopausal and menstrual cycle disorders, with claims of high efficacies by users. This study aimed at assessing fertility hormones of menopausal rats after the administration of the herbs. Materials and Methods: Twenty-five female albino wistar rats divided into Groups A, C, D and E consisting of irregularly cycling menopausal rats and Group B consisting of young regularly cycling rats were used for this study. Groups A and B served as negative and positive control respectively while Groups C, D and E were the experimental groups. Extract administration to the treated groups was for 21 days and animals were sacrificed on the 22nd day (pro-oestrus phase). Blood sample was collected for hormone assay and pituitary glands were dissected out for tissue processing. Results: Statistical analysis of level of serum oestradiol in groups B, C and D showed a significant increase (p<0.05) with the combined extract group recording the highest when compared to the negative control. The value of FSH in combined extract treated group was lower but not statistically significant at p<0.05 when compared with the negative control. Progesterone, LH and testosterone level was not significantly different (p<0.05) among the groups. Cells of the pituitary gland were normal. Conclusion: The findings of this study demonstrate that hormone pattern for the combined extract-treated group was similar to that of positive control. Therefore, combined leaf extracts of these herbs may be useful in the management of sub-fertility associated with peri-menopause and menopause.
  V.A. Fischer , E.F. Onwukwe , C.E. Fischer and P.E. Ebong
  Background and Objectives: The use of medicinal plants and different herbs in the treatment of different ailments by the populace including pregnant women may have some teratogenic effects on the fetuses. Costus afer is a medicinal plant used in tropical Africa in treating inflammation, rheumatism, arthritis, hepatic disorders, miscarriages, epileptic attack and hemorrhoids. This study is aimed at evaluating Costus afer on fetal morphology and cerebral cortex of albino rats. Materials and Methods: Twenty-four female rats weighing between 150 and 180 g divided into 4 groups; Group A (Control), Group B (Low dose), C (Medium dose) and D (High dose) were used. The female rats were mated with mature male rats for pregnancy. Groups B, C and D animals received orally 250, 500 and 1000 mg kg1 b.wt., of ethanolic leaf extracts of Costus afer, respectively on days 7-12 of gestation. On day 19 of gestation, the rats were sacrificed and fetuses examined. Results: Results showed no observable malformation on the external structures of the fetuses. Reduction in the weight, crown-rump length and tail length of the fetuses in treated group B, C and D, when compared to the control group was not significant (p>0.05). Results from the histological examination by using Haematoxylin and Eosin staining technique showed no evidence of alteration of the cerebral cortex of the treated groups when compared to the control group. Conclusion: Ethanolic leaf extract of Costus afer appears to be safe for use during pregnancy with probably no toxic effects on the morphology and histology of the cerebral cortex of fetuses of albino Wistar rat.
  M.U. Eteng , B.J. Bassey , I.J. Atangwho , G.E. Egbung , E.U. Eyong , P.E. Ebong and A.O. Abolaji
  Hypoglycemic and biochemical effects of herbal extracts of Vernonia amygdalina Del. (Compositae), Catharantus roseus (L.) G. Don (Apocynaceace) and chlorpropamide were compared and status of macrovascular complications evaluated using biochemical indices in normal and diabetic rats. The phytochemistry of the herbs was also assessed. Hypoglycemic activity of the herbs and chlorpropamide was evaluated on diabetic and non-diabetic rats but biochemical effects of the treatments was evaluated only on diabetic rats, assigned into four study groups (n = 8). Group I (control) received placebo (30% ethanol), treatment group II was gavaged with chlorpropamide in dose 14.28 mg kg-1 body weight, while groups III and IV were administered extracts of V. amygdalina (400 mg kg-1 body weight) and C. roseus (400 mg kg-1 body weight), respectively in 30% ethanol vehicle for 21 days. Results of the phytochemistry assessment identified alkaloids, cardiac glycosides, saponins, flavonoids, tannins in V. amygdalina and C. roseus. Triterpenes were identified only in V. amygdalina and anthroquinones only in C. roseus. All three treatments produced hypoglycaemic activity in normal and diabetic rats and significantly (p<0.05 to <0.01) reduced triglyceride and total Cholesterol relative to controls. C. roseus alone significantly (p<0.01) elevated HDL-Cholesterol. Serum protein significantly (p<0.05) increased in all treatments compared with controls. Urea levels decreased in all the treatments but more dramatic with chlorpropamide. Aminotransferase activity was not altered except serum ALT which was reduced in treated rats. Electrolyte profile showed dilutional hyponatremia with chlorpropamide treatment, which was absent in C. roseus treatment but mild in V. amygdalina. These changes in biochemical indices of toxicity and macrovascular complications are discussed with respect to the comparative therapeutic benefits of the three treatments.
  F.E. Uboh , M.I. Akpanabiatu , I.J. Atangwho , P.E. Ebong and I.B. Umoh
  The effect of vitamin A on weight-loss, growth-depression and haematotoxicity associated with gasoline vapours exposure was assessed in male and female Wistar albino rats. The rats were exposed to ungraded concentrations of gasoline vapours (6 h daily) for 20 weeks. Vitamin A (retinol) at prophylactic dosage (400 IU kg-1 day-1) was orally administered to the rats in the last two weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), weight gain and growth rate in the male and female rats exposed to the vapours were significantly lower (p<0.05) compared respectively to the levels obtained for male and female control rats. On the other hand, the levels of White Blood Cells (WBC) in the male and female test rats were significantly higher (p<0.05) compared respectively with the level obtained for male and female control rats. These observations indicated that exposure to gasoline vapours produced haematotoxicity, weight loss and growth depression in rats. However, administration of vitamin A was observed to produce a significant regain (p<0.05) in weight-loss, growth-depression and haematotoxicity observed to be associated with exposure to gasoline vapours, although the females were noted to respond more favourably than the males. This suggests that vitamin A may be used to reverse or prevent weight-loss, growth-depression and haematotoxicity in subjects exposed to gasoline vapours.
  I.J. Atangwho , P.E. Ebong , M.U. Eteng , E.U. Eyong and A.U. Obi
  This research assessed the hypoglycemic action of ethanolic extract of Vernonia amygdalina del and its impact on selected indices of kidney function in experimental diabetic rat models. Twenty-one Wistar rats (120-160 g) assigned to 3 groups of seven rats each were used. Groups 1 and 3, constituting the diabetic (DC) and normal controls (NC), respectively were both given placebo treatment, whereas group 2 was the test group of animals administered the extract (400 mg kg-1 body weight) by gastric-intubation for 14 days. Results of analyses of serum electrolytes and biochemical indices showed: significant reductions (p<0.05) in glucose, urea and sodium concentrations of the V. amygdalina ethanolic extract treated group (144.14±25.83, 81.60±16.52 and 65.00±6.24, respectively) relative to their respective controls (247.25±4.83, 122.08±10.60 and 116.62±12.00). Serum chloride levels of the test group also reduced, whereas, that of potassium and creatinine were elevated with respect to their normal control values. However, these later changes were non-significant (p>0.05). Histological changes in the kidney tissues such as necrosis of tubules, degeneration of cells of glomerular capsule and partial obliteration of glomerular tuft observed in diabetic animals were reversed in extract treated diabetic group. Vernonia amygdalina extract besides its hypoglycemic action, can protect against kidney impairments due to diabetes, but may induce dilutional hyponatraemia.
  F.E. Uboh , M.I. Akpanabiatu , Y. Alozie , E.E. Edet , J.I. Ndem and P.E. Ebong
  Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
  C.N.C. Ugochukwu , P.E. Ebong and E.U. Eyong
  This study determined the influence of doses of halofantrine hydrochloride, a phenanthrene methanol drug used in the therapeutic treatment of malaria on the estradiol levels of female wistar rats. A suspension of the drug at a dose of 0.5ml/kg and 1ml/kg body weight three times at six hourly intervals were administered orally to different groups of mature female rats for 5 and 10 days duration, control groups received similar treatment doses of normal saline. The animals were sacrificed on the 5th and 10th day after drug administration by cervical dislocation. Whole blood samples were collected for white blood cell count. From the plasma, the hormonal level was determined by radio-immunoassay and the activities of AST, ALT and ALP were also determined. The level of estradiol following 5 and 10 days treatment was higher significantly (p<0.05) in both groups compared to the control. The activities of ALT, AST and ALP increased significantly (p<0.05). The white blood cell count also increased in a dose dependent manner. These findings suggest that the drug might have some hepatotoxic effects.
 
 
 
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