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Articles by P.D. Lokhande
Total Records ( 4 ) for P.D. Lokhande
  S.C. Jagdale , B.S. Kuchekar , A.R. Chabukswar , P.D. Lokhande and C.G. Raut
  Myocardial ischemia is a serious cardiac problem which should be diagnosed and treated effectively to prevent its complications. Many plant based medicine have been utilized for the effective treatment in cardiac problems. Myocardial ischemia was induced in rats by administration of isoproterenol. Petroleum ether extract of root and piperine from roots of Piper longum Linn. were subjected for evaluation of their anti-oxidant activity by DPPH scavenging method. Lipid peroxide and Glutathione values in myocardial ischemic rats have also been estimated by inducing myocardial ischemia by using isoproterenol. It has been found that at 50 mg mL-1 concentration pet ether extract and piperine exerts 74.12 and 72.13% of inhibition. Pet ether extract and piperine pretreatment decreases lipid peroxide level and maintain glutathione content to near normal in treated rats. The present study shows that the extract of the root of the plant and piperine exert anti-oxidant activity and are protective in the myocardial ischemic condition.
  P.D. Lokhande , K.R. Gawai , K.M. Kodam , B.S. Kuchekar , A.R. Chabukswar and S.C. Jagdale
  Dry roots of the plant Piper longum were extracted with n-hexane. The constituents were isolated and purified by column chromatography. The structures of the isolated constituents were confirmed by spectral analysis. The isolated constituents and n-hexane extract were found to show varying degree of antibacterial activity against all the tested bacteria. However, the aqueous extract did not show antibacterial activity against the tested bacteria. The isolated constituents were found to show better activity profile than the n-hexane extract, which indicates that the isolated constituents might be responsible for the antibacterial activity. The Minimum Inhibitory Concentration (MIC) value of piperine against Bacillus cereus and Escherichia coli was found to be 12.5 mg mL-1.
  P.D. Lokhande , K.R. Gawai , K.M. Kodam , B.Y. Waghmare , A.R. Chabukswar and S.C. Jagdale
  Until recently the incidence of life-threatening fungal infections was considered to be too low to warrant extensive research, however over the last two decades infections caused by fungi have emerged as a growing threat to human health and there are studies indicating that the situation will become worse in the near future. Polyene antibiotics like nystatin and amphotericin B are widely employed for antifungal activities. Nystatin is used to clear candidosis and amphotericin B is useful in the treatment of deep-seated mycoses. Other polyene antibiotics like primaricin, hamycin, trichomycinare and candicidin have been used to a limited extent, for the treatment of localized mycotic infections. However, the polyene antibiotics especially aureofungin are less extensively used for the therapeutic treatment due to their toxicity and particularly less water solubility. The solubility of these antibiotics may play an important role in the enhancement of their therapeutic activity, keeping this view in mind, we have prepared water soluble amide derivatives of aureofungin, seven derivatives have been prepared and six of them were found to be active as antifungal agents when tested against Candida albicans. The structures of the derivatives were confirmed by UV and IR spectroscopy. The Minimum Inhibition Concentration (MIC) was found to be 1000 μg mL-1.
  P.D. Lokhande , B.S. Dhaware , S.C. Jagdale , A.R. Chabukswar and A.L. Atre
  Extract of the plant Piper longum Linn (Family: Piperaceae) is used as folk medicine in India and China. Roots of the plant Piper longum are reported for the treatment of heart diseases in ancient literature of East Asia. However, no data is available on exact role of fractions of plant in heart diseases. In the present study we have isolated four major fractions namely F, G, H and I and the activity of the fractions was studied on isolated frog heart. Fraction F has produced negative inotropic and negative chronotropic effect on isolated frog heart at 200 μg mL-1. Fraction F shows maximum antagonistic activity on beta-receptors by decreasing heart rate and force of contraction. Actions of Adrenaline are blocked by fraction F and in the presence of propanolol, it shows continuous decrease in heart rate and force of contraction. In the present study, it was observed that fraction F shows antagonistic activity on beta adreno-receptors.
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