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Articles by P. Trivedi
Total Records ( 3 ) for P. Trivedi
  Ashutosh Jamloki , C. Karthikeyan , S.K. Sharma , N.S. Hari Narayana Moorthy and P. Trivedi
  A quantitative structure-activity relationship study on 6-aryl-pyrazolo (3,4-b) pyridines was performed to gain structural insight into the binding mode of the molecules to the glycogen synthase kinase -3α, an enzyme phosphorylate and inhibit Glycogen Synthase (GS) which is the rate limiting enzyme in the glycogen biosynthesis. The molecular modeling studies were performed using CS Chem. Office 2001 molecular modeling software version 6.0. Allinger`s MM2 force field by fixing Root Mean Square Gradient (RMS) to 0.1 Kcal mol-1 and semiemperical AM1 Hamiltonian method (MOPAC module) were used to minimize the energy and calculate descriptors. The thermodynamic and steric features of 6-aryl-pyrazolo (3,4-b) pyridines are highly correlated with GSK-3α inhibitory activity. The results of the study suggests that introduction of bulky groups at C-5 position of the pyrazolopyridine ring will increase the GSK-3α inhibitory potency as it may involve in hydrophobic interaction with the ATP binding site of the enzyme. The results of the study reveal that the conformational rigidity and orientation of molecule play significant role in the GSK-3α inhibitory activity. Additionally, electronic interactions between molecule and enzyme were found to be crucial for GSK-3α inhibitory activity.
  C.M. Lucksha , D. Agarwal , N.S.H.N. Moorthy , C. Karthikeyan and P. Trivedi
  Synthesis and biological evaluation of amino acid conjugates of cinmetacin was carried out to improve some pharmacokinetic properties and to minimize some undesirable side effects (especially ulcerogenic effect). Dissolution studies and hydrolysis studies on simulated intestinal fluid (pH 7.4) follow the first order kinetics. The quantitative structure property relationship studies reveals that rate of hydrolysis of the compounds is inversely related to partition coefficient values. The study of acute and chronic anti-inflammatory and ulcerogenic activity gave statistically significant results and it concluded that the compounds minimize the gastric side effects of cinmetacin remarkably.
  S. Singh , B. Bikram , J. Mishra , P. Trivedi , Rai Ajay Kumar , S. M. Yadav and Asha Sinha
  To encounter the acute shortage of properly decomposed organic manure the present study was conducted for investigating the pattern of decomposition of the temple waste. Isolation of the fungi from decomposing temple waste and soil mixed with manure was done by direct observation method, damp chamber incubation method and dilution plate technique. Total 28 fungus were isolated and highest fungal population was recorded by dilution plate technique followed by damp chamber and then direct observation method and according to their occurrence they were divided into three categories (1) Dominant fungi which show 70% frequency, (2) Common fungi which shows less than 70% frequency and (3) Rare fungi were observed once or twice during isolation. The moisture content of the decomposing temple waste recorded maximum 29.65% at 15 days of intervals. Deuteromycotina fungi were recorded highest 64.28% in comparison to Zygomycotina (7.14%) and Ascomycotina (3.5%). In early stages of infection Mucor racemosus, Rhizopus nigricans Alternaria alternata, Fusarium spp. were found abundantly but in later stages of decomposition prevalence of Aspergillus niger, Aspergillus flavus, Aspergillus fumigates, Aspergillus candidus, Penicillium rubrum, Penicillium citrinum was recorded. During the process of decomposition the moisture content of the temple waste gradually decreases whereas changes in pH follow an erratic pattern due to the activity of above mentioned mycoflora throughout the process of biodegradation.
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