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Articles by P. Rajesh
Total Records ( 4 ) for P. Rajesh
  V. Rajesh Kannan , G. Stalin Rajasekar , P. Rajesh , V. Balasubramanian , N. Ramesh , E. King Solomon , D. Nivas and S. Chandru
  The present study intended to evaluate the beneficiary effects of ethanolic extract of Terminalia chebula Retz. fruits (EETC) by using alloxan-monohydrate induced diabetic control by using Wistar Albino rats. The toxicity study was performed on aliquot doses of EETC (100 to 500 mg kg-1 b.wt.) and predetermined the LD50 value on 30 days evaluation; also the behavioral changes, symptoms and mortality have been checked, the EETC showed the nil toxicity up to 500 mg kg-1 b.wt. The effect of EETC (200 mg kg-1 b.wt.) was compared with the glibenclamide (600 mg kg-1 b.wt.) that is often used as a standard drug and the anti-diabetic activity has been conducted for 30 days. After the completion of the study, animals were dissected through cervical dislocation and collected the blood, serum and pancreas. The collected samples were performed under parameters like biochemical and anti-oxidant enzymes related to diabetes such as, weight variation, blood glucose, plasma insulin, serum and liver protein, serum and liver cholesterol, serum and liver triglyceride, serum and liver phospholipids, SGOT (Serum Glutamate Oxaloacetic Transaminase), SGPT (Serum Glutamate Pyruvate Transaminase), ACP (Acid Phosphatase), ALP (Alkaline Phosphatase), GSH (Glutathione reductase), GPT (Glutamate Pyruvate Transaminase), GPX (Glutathione Peroxidase) ,CAT (Catalase) and histopathological sections of the pancreas, the above parameters calculated and showed that the significance at p<0.001 to 0.05. The histopathological changes caused after induction of alloxan showed the granular cytoplasm, dilatation, shrunken nuclei and inflammation, which were reduced after treatment of the EETC (200 mg kg-1 b.wt.). Excess proliferation of epithelium in the pancreas was observed in diabetic rats, which was reduced after administration of the EETC (200 mg kg-1 b.wt.). From the evaluation of the present study on EETC has been confirmed that having the pharmacological action against the diabetic condition, even though the mechanism of the action is unknown, also it can be used further molecular compound analysis and define the chemical to the action.
  R. Mahalakshmi , P. Rajesh , N. Ramesh , V. Balasubramanian and V. Rajesh Kannan
  The present study was intended to evaluate the hepatoprotective activity on ethanolic extract of leaves of Vitex negundo was determined by using Wistar Albino rats in male sex. The V. negundo Linn. is a natural plant product, in it’s the leaves are used with the added advantage to revert Ibuprofen induced hepatotoxicity. Oral administration of ethanol extract of V. negundo (100 and 300 mg) produced a significant and dose dependent inhibition to the acute hepatotoxic induced rats and various parameters were analyzed, when compared with negative control V. negundo showed that the significant activity in 300 mg/kg/b.wt. They exhibited a significant inhibition of hepatic toxicity by using various marker enzymes and the histopathological analysis. The inhibitory effect of the V. negundo on hepatotoxicity was compared to that of positive control group. The various parameters such glucose, protein, triglycerides, bilirubin, urea, creatinine, ALP, ACP, SGPT, SGOT and histopathological parameters was measured by dissection the rats. A significant index and values were observed in the acute assays; an effective significant alteration in all biochemical and histopathological sections was observed. From these results, concluded that the V. negundo having the potential effectiveness at the dose of 300 mg/kg/b.wt., (p<0.01) significance in a dose dependent manner. These results suggest that leaves of V. negundo having the hepatoprotective activity, which support the hepatic cells protection.
  S. Mohamed Mansoor Roomi , P.L. Muthu Karuppi , P. Rajesh and B. Guru Revathi
  Problem statement: Image sensors and communication channels often introduce impulse noise in image transmission. The most common filters available to remove such noise are median filter and its variants but the major drawbacks identified with them are blurring of edge detail and low noise suppression. To preserve the sharp and useful information in the image, the filtering algorithms are required to have intelligence incorporated in them. Approach: This research proposed a particle swarm optimization based approach in the design of filter. The filter weights were adapted and optimized directionally to restore a corrupted pixel in a mean square sense. Results: This results in replacement of noisy pixels by near originals along its edge direction. Various objective parameters like Mean Absolute Error (MAE), percentage of noise elimination, percentage of pixels spoiled showed that the proposed recursive no-reference filter performs 4dB better than the competing filters. Conclusion: This research aimed at presenting a new filtering framework for impulse noise removal using Particle Swarm Optimization (PSO).
  P. Rajesh and P. Ramasamy
  Single crystals of DL-malic acid-doped ammonium dihydrogen phosphate have been grown using slow evaporation method and also by Sankaranarayanan–Ramasamy (SR) method with the vision to improve the properties of the ADP crystals. The characterization of grown crystals was made by single-crystal X-ray diffraction, powder X-ray diffraction, UV–vis. spectroscopy, Fourier transform infrared spectroscopy (FTIR), differential thermal analysis (DTA), Vicker's microhardness, dielectric measurements, high-resolution X-ray diffraction (HRXRD) and second-harmonic studies. Structural difference between pure and doped crystal has been studied by XRD analysis. Functional groups were identified by FTIR spectroscopy. The grown crystals were found to be transparent in the entire visible region. Decomposition temperatures of the grown crystals were measured by DTA. Vicker's hardness study carried out on (0 0 1) face at room temperature shows increased hardness of the doped crystals and SR-method-grown crystals. Dielectric measurements reveal that SR-method-grown DLM-doped ADP crystals have low dielectric loss. Crystalline perfection of the grown crystals is analyzed using HRXRD. Preliminary measurements indicate that the second harmonic generation efficiency of the doped crystals at a fundamental wavelength of 1064 nm is roughly 1.5 times greater than that of pure ADP.
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