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Articles by P. Promwichit
Total Records ( 5 ) for P. Promwichit
  J. Anbu Jeba Sunilson , R. Suraj , G. Rejitha , K. Anandarajagopal , A.V. Anita Gnana Kumari and P. Promwichit
  In the present study, antimicrobial activity of various extracts of Zingiber officinale, Curcuma longa and Alpinia galanga were screened against the common food borne bacteria such as Escherichia coli, Salmonella enteriditis, Clostridium perfringens, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus and fungi such as Saccharomyces cerevisiae, Hansenula anomala, Mucor mucedo, Candida albicans using disc diffusion method. All the extracts showed significant antibacterial and antifungal properties. The methanol extracts (100 μg mL-1) revealed maximum zone of inhibition (p<0.001). Zingiber officinale and Curcuma longa possessed considerably greater activity than Alpinia galanga. These findings established the potential of the selected rhizomes of Zingiberaceae family as effective natural food preservatives.
  J. Anbu Jeba Sunilson , R. Suraj , K. Anandarajagopal , G. Rejitha , M. Vignesh and P. Promwichit
  In this study, petroleum ether, chloroform and methanol extracts of Codium decorticatum showed the presence of amino acids, carbohydrates, saponins, phytosterols, alkaloids and glycosides. The antibacterial activity against Gram-positive bacteria, such as Streptococcus pneumoniae, Staphylococcus aureus and Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae, Salmonella typhi, Pseudomonas aeruginosa was carried out using cup-plate method. All the extracts showed good zone of inhibition against S. pneumoniae and K. pneumoniae at the concentrations of 25, 50 and 100 mg mL-1 compared with standard drugs, gentamicin and ampicillin (30 μg mL-1). To standardize the algae, elemental analysis was also carried out on C. decorticatum powder which revealed the presence of various elements. The present findings show the importance of C. decorticatum in producing new compounds having antibacterial activity.
  J. Anbu Jeba Sunilson , G. Rejitha , K. Anandarajagopal , Amitava Das , M. Muthappan and P. Promwichit
  Leaves of Cayratia carnosa have been ethnomedically claimed to possess a wide array of biological activities including anticancer activity. To verify the folklore claim, this study was performed in a Human breast carcinoma cell lines, MCF-7 and MDA-MB-231. Methanol and aqueous extracts of the leaves of C. carnosa showed cytotoxic effect on MCF-7 and MDA-MB-231 cell line, as determined with 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) microculture tetrazolium viability assay. Subcellular alterations were evaluated by using normal inverted microscope. Cells treated with methanol extract showed degeneration of cytoplasmic organelles, profound shrinkage of cells and apoptotic characteristics. The results showed that the methanol extract possesses cytotoxic effect which was greater than aqueous extract when compared to that of the control.
  J. Anbu Jeba Sunilson , R. Varatharajan , P. Jayaraj , T. John , J. Jisha and P. Promwichit
  Ethanol extract of Hibiscus aculeatus (HAE) was assessed in different acute and chronic gastric ulcer models in rats. HAE, 50-200 mg kg-1 administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (9.21-52.63% protection, p<0.05), aspirin (23.95-56.25% protection, p<0.05), ethanol (13.55-58.47% protection, p<0.05), cold-restraint stress (18.34-72.92% protection, p<0.05 to p<0.001) and acetic acid (p<0.05 to p<0.001) induced acute and chronic ulcers. HAE also significantly (p<0.001) reduced the ulcer incidence (40 and 10%) and severity (54.35 and 85.37% protection) of duodenal ulcer, induced by cysteamine. HAE offered protection (49.57 and 58.97%) against ethanol-induced depletion of gastric wall mucus. And also, HAE reduced the ulcer index with significant decrease in plasma corticosterone (21.15 and 33.51% protection, p<0.05), lipid peroxidation (16.66 and 38.88% protection, p<0.01 and p<0.001), superoxide dismutase (17.64 and 47.25% protection, p<0.05 and p<0.001) and an increase in catalase (25.84 and 83.14% protection, p<0.05 and p<0.001) activity respectively. Preliminary phytochemical screening of the HAE showed positive test for flavanoids, terpenoids, steroids, tannins and saponins. The results indicate that HAE possesses gastroprotective and antioxidant activity.
  J. Anbu Jeba Sunilson , M. Muthappan , Amitava Das , R. Suraj , R. Varatharajan and P. Promwichit
  Coccinia grandis Linn. (Cucurbitaceae) is a perennial branched handsome tendril climber, distributed through out India. It has been used in folk medicine for the treatment of jaundice. The aim of this work was to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the leaves of C. grandis against liver damage induced by CCl4 in rats. The ethanolic extract at an oral dose of 200 mg kg -1 exhibited a significant (p<0.05) protective effect as shown by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing levels of total protein and albumin levels as compared to silymarin, the positive control. These biochemical observations were supported by histopathological examination of liver sections. The activity may be due to the presence of flavonoid compounds. The extracts showed no signs of acute toxicity up to a dose level of 2000 mg kg -1. Thus it could be concluded that ethanolic extract of C. grandis leaves possesses significant hepatoprotective activity.
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