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Articles by P. Pothier
Total Records ( 2 ) for P. Pothier
  K. Ambert-Balay , M. Lorrot , F. Bon , H. Giraudon , J. Kaplon , M. Wolfer , P. Lebon , D. Gendrel and P. Pothier
  Aichi virus has been proposed as a causative agent of gastroenteritis. A total of 457 stool specimens from children hospitalized with acute diarrhea and 566 stool specimens from adults and children involved in 110 gastroenteritis outbreaks were screened for the presence of Aichi virus by reverse transcription-PCR (RT-PCR) amplification of the genomic region of the 3C and 3D (3CD) nonstructural proteins. Our results show a low incidence of Aichi virus in pediatric samples and the existence of mixed infections with other microbiological agents in some cases. From the outbreak survey, it appears that the presence of Aichi virus is an indicator of mixed infections causing gastroenteritis outbreaks and that it could be involved in half of the oyster-associated outbreaks. A second RT-PCR was developed to amplify a part of the VP1 gene. The phylogenetic analysis showed a good correlation between the two classifications based on 3CD and VP1 gene sequences and revealed the prevalence of genotype A in France. It also allowed us to partially describe an Aichi virus strain that could represent a new genotype, thus suggesting the existence of a certain diversity.
  A. Kroneman , L. Verhoef , J. Harris , H. Vennema , E. Duizer , Y. van Duynhoven , J. Gray , M. Iturriza , B. Bottiger , G. Falkenhorst , C. Johnsen , C.-H. von Bonsdorff , L. Maunula , M. Kuusi , P. Pothier , A. Gallay , E. Schreier , M. Hohne , J. Koch , G. Szucs , G. Reuter , K. Krisztalovics , M. Lynch , P. McKeown , B. Foley , S. Coughlan , F. M. Ruggeri , I. Di Bartolo , K. Vainio , E. Isakbaeva , M. Poljsak-Prijatelj , A. Hocevar Grom , J. Zimsek Mijovski , A. Bosch , J. Buesa , A. Sanchez Fauquier , G. Hernandez-Pezzi , K.-O. Hedlund and M. Koopmans
  The Foodborne Viruses in Europe network has developed integrated epidemiological and virological outbreak reporting with aggregation and sharing of data through a joint database. We analyzed data from reported outbreaks of norovirus (NoV)-caused gastroenteritis from 13 European countries (July 2001 to July 2006) for trends in time and indications of different epidemiology of genotypes and variants. Of the 13 countries participating in this surveillance network, 11 were capable of collecting integrated epidemiological and virological surveillance data and 10 countries reported outbreaks throughout the entire period. Large differences in the numbers and rates of reported outbreaks per country were observed, reflecting the differences in the focus and coverage of national surveillance systems. GII.4 strains predominated throughout the 5-year surveillance period, but the proportion of outbreaks associated with GII.4 rose remarkably during years in which NoV activity was particularly high. Spring and summer peaks indicated the emergence of genetically distinct variants within GII.4 across Europe and were followed by increased NoV activity during the 2002-2003 and 2004-2005 winter seasons. GII.4 viruses predominated in health care settings and in person-to-person transmission. The consecutive emergence of new GII.4 variants is highly indicative of immune-driven selection. Their predominance in health care settings suggests properties that facilitate transmission in settings with a high concentration of people such as higher virus loads in excreta or a higher incidence of vomiting. Understanding the mechanisms driving the changes in epidemiology and clinical impact of these rapidly evolving RNA viruses is essential to design effective intervention and prevention measures.
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