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Articles by P. Panneerselvam
Total Records ( 3 ) for P. Panneerselvam
  D. Sivaraman , P. Muralidharan and P. Panneerselvam
  Alzheimer’s disease is a primary degenerative disease of the central nervous system. The progression of Alzheimer’s disease will ultimately lead to dementia, behavioral and cognitive impairments. Alzheimer’s is the commonest cause of dementia, a group of progressive condition which involves especially short-term memory loss, poor concentration, poor sense of time and space, difficulty in finding words or understanding other people, difficulty in perceiving and interpreting surroundings, mood changes and emotional upsets. The present study was designed to determine the ameliorating effect of ethanolic leaf extract of Ficus hispida Linn. (EEFH) on (amyloid beta) Aβ 25-35-induced cognitive deficits and oxidative stress in mice. Animals were treated with EEFH for periods of 4 weeks dose-dependently (200 and 400 mg kg-1) then received a single intracerebroventricular (i.c.v.) injection of Aβ 25-35 (10 μg mouse-1). Behavioral changes in the mice were evaluated using passive avoidance, Y-maze, Hole board and water-maze tests. Anti-oxidant enzymes and neuro-transmitter levels were also been estimated. EEFH at the dose of 400 mg kg-1 significantly ameliorated the cognitive and memory deficits caused by i.c.v. injection of Aβ 25-35. EEFH attenuated the Aβ-induced increase in brain levels of thiobarbituric acid reactive substances. There was an increase in glutathione peroxidase, glutathione reductase and super oxide dismutase activity in EEFH treated groups. The acetyl cholinesterase activity in the brain was lower in EEFH supplemented groups than the Aβ-injected group. EEFH treated group showed a significant alteration in behavior when compare to negative control in Y maze, Plus-maze and also in water maze tests. These findings suggest EEFH exerts a protective effect against cognitive deficits induced by Aβ 25-35 accumulation in Alzheimer’s disease, because of its potential antioxidant property.
  D. Sivaraman , P. Panneerselvam and P. Muralidharan
  Alzheimer’s disease is a progressive neurodegenerative disorder primarily manifesting as a loss of memory, senile dementia, intra neuronal neurofibrillary tangle formation and cerebral parenchyma deposition of the β-amyloid protein in the form of amyloid plaques is the most stereotypic cognitive and neuropathological hallmarks of AD. The present study was designed to determine the ameliorating effect of hydroalcoholic extract of Ipomoea aquatica (HAEIA) on amyloid beta (Aβ) 25-35-induced cognitive deficits and oxidative stress in mice. Animals were treated with HAEIA for periods of 4 weeks dose-dependently (200 and 400 mg kg–1) then received a single Intra Cerebro Ventricular (ICV) injection of Aβ 25-35 (10 μg/mouse). Cognitive behavioral changes in the mice were evaluated using step down inhibitory avoidance, object recognition test, y-maze, hole board, elevated plus maze and water-maze tests. Brian level neurotransmitter such as dopamine, noradrenaline serotonin, glutamate and metabolic enzymes like acetylcholineserase, monoamine oxidase A and B estimated by using spectrofluorimeter technique. Results obtained from the study indicate that HAEIA at the dose of 400 mg kg–1 significantly ameliorated the cognitive and memory deficits caused by ICV injection of Aβ 25-35. The acetyl cholinesterase, monoamine oxidase and glutamate activity in the brain was lower in HAEIA supplemented groups than the Aβ-injected group. The HAEIA significantly improves the level of serotonin, dopamine, nor-adrenaline in treatment group when compare to Aβ-injected group. In conclusion plant like ipomoea auatica often served has a valuable lead for the clinical management of AD with minimal side effects.
  D. Sivaraman , P. Panneerselvam , P. Muralidharan and T. Purushoth Prabhu
  Objective: The present investigation was carried out to evaluate the safety of an hydroalcholic extract of Ipomoea aquatica Forsk (HAEIA) leaves by determining its potential toxicity after acute and sub-acute administration in rodent. Materials and Methods: For the acute study HAEIA was administered in single doses of 500, 1000 and 2000 mg kg-1 (p.o). General behavior, adverse effects and mortality were determined for up to 14 days. The sub-acute toxicity test was based on the daily administration of two doses of HAEIA (200 and 400 mg kg-1 body weight) for four weeks, 0.1% CMC served as control group. Results: In the acute and sub-acute study hydroalcoholic (Water plus ethanol) extract of Ipomoea aquatica leaves doesn’t caused any change in general behavior, adverse effects and mortality. Throughout the study period no sign of toxicity was registered. Conversely, the sub-acute doses stimulated slight increase in body weight of the animals treated test drug. Further it was observed that HAEIA at the dose of 200 and 400 mg kg-1 did not modify the weight index. It was evident that daily oral dose of HAEIA at at both the dose level for 28 day days did not shown any significant change in hematological parameters and also no change observed in biological analysis of serum Aspartate transaminase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), bilirubin, creatinine, Blood Urea Nitrogen (BUN) levels. Conclusion: In view of the results obtained through acute toxicity and sub-acute study of Ipomoea aquatica (Water Spinach) which is consumed as a traditional medicine of india and china. No significant changes were observed in organ weights and histopathological results showed normal profile suggesting no morphological alterations there is a wide margin of safety for the therapeutic use of this plant was proved through this study which enables the research to carry out the lead invention from the natural resources.
 
 
 
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