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Articles by P. Chinnaswamy
Total Records ( 4 ) for P. Chinnaswamy
  P. Uma Devi and P. Chinnaswamy
  The aim of the present study was to estimate the effect of age and gender on the levels of primary and secondary antioxidants and Malondialdehyde in red blood cells of the selected Schizophrenia patients. In our present study, the activities of six free radical scavenging enzymes (super oxide dismutase (SOD), catalase (CAT)), glutathione peroxidase (GSH-Px), glutathione Transferase (GST), glucose-6-phosphate dehydrogenase (G6PD), Caeruloplasmin ferroxidase (Cp) and the level of thiobarbituric acid-reactive substances (TBARS) as an index of lipid per oxidation were analyzed in the different age groups of schizophrenia patients. Role of gender was also analyzed in both schizophrenia and control subjects. It was observed from the results that there was a significant increase in erythrocyte MDA levels and activity of SOD and a significant decrease in erythrocyte CAT,GSH- Px, Cp-ferroxidase and G6PD levels in patients with schizophrenia, when compared to controls (p<0.01). The results have also shown that among different age groups, highly significant oxygen free radical production, evidenced by increased levels of MDA and decreased levels of antioxidant enzymes activity was found in adult and elderly schizophrenia patients, which supports the more pronounced oxidative stress in adult and elderly schizophrenia patients when compared to young schizophrenia patients. The statistically more significant increase (p<0.001) in the activity of SOD in elderly schizophrenia subjects may be a compensatory regulation in response to increased oxidative stress in elders. The decreased concentrations of the CAT, GSH-Px, G6PD and Cp-ferroxidase support the hypothesis that lipid per oxidation is an important causative factor in the pathogenesis of schizophrenia. These data reveal that antioxidant defense mechanisms might be impaired a lot in normal elderly people and schizophrenia patients with age group above 30 (i.e., adults and elders). As for as gender concerned, we observed a significant raise in the levels MDA, SOD and significant decrease in the levels of selected antioxidant enzymes in schizophrenia male and female subjects when compared with the respective control male and female subjects (p<0.01). But we found statistically more significant increase in the levels of MDA and highly significant decrease in the levels of the secondary antioxidant enzymes G6PD and Cp ferroxidase (p<0.001) were found in schizophrenia males when compared with schizophrenia females. Supplementation of antioxidants may prevent further oxidative injury in elderly schizophrenia patients.
  M. Sathya and P. Chinnaswamy
  Bladder cancer is the one of the most common genito urinary tract malignancy and more than 90% of bladder cancer is of urothelial carcinomas that ranks fourth among cancers occurring in males. Although, over 50% of cases are diagnosed by biopsy at an early stage. The prognosis is sometimes difficult to assess because of heterogeneity, multifocality and tumor recurrence. In the present study, among 70 urinary bladder tumor patients, 61 (87%) were of Transitional Cell Carcinoma (TCC) and 9 (13%) of adenocarcinoma. Similarly, in the observed TCC patients, high grade is observed in 44 cases (63%) whereas low grade was in 17 cases (24%). The study also revealed among the TCC, 18 (25%) patients have shown the muscle invasion, 61 (87%) with lamina propria invasion and 18 (25%) patients with lymph vascular space invasion.
  P. Uma Devi , S. Murugan , S. Suja , S. Selvi , P. Chinnaswamy and E. Vijayanand
  The aim of this study is to evaluate the antibacterial efficacy of Achyranthes bidentata against seven different microorganisms such as Escherichia coli, Bacillus subtilin, Proteus vulgaris, Salmonella typhi, Staphylococcus aureus, Pseudomonas species and Klebsiella pneumoniae. The values of zone of inhibition were measured and compared with standard values. All the extracts of root, stem, leaves and flowers showed high sensitive to Proteus, Escherichia coli, Bacillus subtilin, Salmonella typhi, Klebsiella pneumoniae, moderate and less sensitivity to Staphylococcus aureus and Pseudomonas species. The antiperoxidative effect of various parts of Achyranthes bidentata was also done. Goat liver was used as the lipid source. This in vitro evaluation was done by the measurement of thiobarbituric acid reactive substances (TBARS) in the experimental mixtures of tissue homogenates. The results suggest that the ethanolic extracts of Achyranthes bidentata root and flowers possessed significant in vitro lipid peroxidation inhibiting activities, which is possibly attributed to its free radical scavenging properties. All the parts of plant extracts were subjected to qualitative analysis to find out phytoconstituents present in them. Results showed the presence of alkaloids, flavonoids, phenols, and steroids and the absence of saponins, glycosides and tannins.
  S. Selvi , P. Uma Devi , S. Suja , S. Murugan and P. Chinnaswamy
  The modulation of the mushroom used now-a-days in the field of medicine, is the way where this is partly achieved. Among these, the `antioxidants` which are capable of deactivating the free radicals follow either enzymatic or non-enzymatic pathways. The aim of this project is to incorporate the non-enzymatic antioxidant in fresh and dried form of powered samples of the oyster mushroom (P. leurotus florida) and milky mushroom (Calocybe indica). This study revealed the presence of non-enzymatic antioxidant in the selected samples and the striking feature of this work is to maximize the usage of mushrooms in the powdered form when there is certain unstable conditions for the usage of mushroom in the fresh form.
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