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Articles by P. Amoateng
Total Records ( 4 ) for P. Amoateng
  G.A. Koffuor , E. Woode and P. Amoateng
  The hypoglycaemic effect of the ethanolic Tragia tennifolia Extract (TTE) was studied in Sprague-Dawley rats subjected to Oral Glucose Tolerance Test (OGTT), Fasting Plasma Glucose Test (FPGT) and alloxan-induced diabetes mellitus. Acute toxicity studies were also conducted on Sprague-Dawley rats. TTE (53 mg kg-1, p.o.) significantly (p≤0.01) reduced the peak plasma glucose concentration and the AUC of the OGTT curve, by 47.0 and 44.9%, respectively 1 h after its administration and this was comparable to that produced by glibenclamide (0.14 mg kg-1) and metformin (12.14 mg kg-1). TTE like glibenclamide, significantly (p≤0.01) reduced the fasting plasma glucose by 29.1% after 5 h compared to control groups. The AUC for TTE-treated rats was reduced by 14.8%. In alloxan-induced DM rats, insulin (8.5 unit/kg/day) significantly (p≤0.01) reduced hyperglycaemia by 68.6% whereas TTE, glibenclamide and metformin had no significant effects. Acute toxicity studies showed no evidence of toxicity after an oral administration of TTE (0.1-0.5 g kg-1). These results indicate that TTE may be potentially useful in Non-insulin Dependent Diabetes Mellitus (NIDDM) but not for Insulin Dependent Diabetes Mellitus (IDDM).
  A. Boye , G.A. Koffuor , P. Amoateng , E.O. Ameyaw and A.K. Abaitey
  This study presented the analgesic and safety assessment of Heliotropium indicum, a plant traditionally used for the management of abdominal pains, dysmenorrhoea and post-labour inflammatory conditions in Ghana using formalin-induced pain model in mice. For comparison of analgesic effect, morphine (1-10 mg kg-1) and diclofenac sodium (1-10 mg kg-1) were used as a reference opioid and NSAID, respectively. The aqueous and ethanolic extracts (30-300 mg kg-1) dose-dependently inhibited both the first and second phases of the formalin-induced nociception. Oral doses of the aqueous extract (1-5 g kg-1) in imprint control region mice were well tolerated in acute toxicity studies; however a 14-day oral administration of 1-2 g kg-1 of the extracts in sprague-Dawley rats produced pathologic effects on the heart, kidney, liver and lungs. Therefore, although the aqueous and ethanolic extracts of H. indicum have analgesic activity, it could have a cumulative toxic effects hence prolonged and continuous use is not advised.
  E. Woode , P. Amoateng , C. Ansah and M. Duwiejua
  This study presents the effect of an ethanolic extract of the whole plant of Synedrella nodiflora, a plant used in Ghana for the treatment of epilepsy and pain, in formalin-induced pain and acetic acid-induced writhing assay and the possible mode(s) of action of its analgesic action. For comparison, morphine and diclofenac were used as standard opioid and NSAID respectively. The ethanolic extract (100-1000 mg kg-1; p.o.) and morphine (1-10 mg kg-1; i.p.) dose-dependently decreased both phases of the formalin-induced nociceptive behavior. The antinociceptive effect of S. nodiflora (300 mg kg-1 p.o.) on the first and second phases of formalin induced pain was significantly blocked by caffeine but not by naloxone. In the acetic acid- induced writhing test, diclofenac and S. nodiflora significantly reduced the number of writhes dose dependently. Also, the effect of S. nodiflora (300 mg kg-1 p.o.) was blocked by caffeine (3 mg kg-1 i.p.) but the analgesic effect of diclofenac was enhanced significantly. The observed effects of caffeine on the central and peripheral analgesic effects of S. nodiflora in the formalin and acetic acid induced writhing suggest the possible involvement of adenosinergic mechanism(s).
  G.A. Koffuor and P. Amoateng
  The aim of this study was to investigate the antioxidant and anticoagulant activities of the ethanolic extract of Phyllanthus fraternus. The antioxidant and anticoagulant activity of an ethanolic extract of Phyllanthus fraternus (gulf leaf-flower) was evaluated using in vitro and in vivo experimental models. The results obtained indicate that the extract of P. fraternus (PFE) exhibits antioxidant activity by significantly scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, concentration-dependent reducing capacity and inhibition of lipid peroxidation. Detection of phenols in the extract gave preliminary evidence of its possible antioxidant activity which correlated with the total antioxidant capacity. The extract significantly increased in vitro clotting time and bleeding time in rabbits. Heparin and aspirin exhibited similar effects. Since thrombus formation and oxidative stress are known to be main risk factors contributing to stroke, the anticoagulant and antioxidant activity in the plants makes it useful as adjuncts in the management of stroke and other neurodegenerative disorders.
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