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Articles by P. Visweswara Rao
Total Records ( 2 ) for P. Visweswara Rao
  G. Narasimhulu , T. Lavanya , S. Rajeswara Reddy , K. Mallikarjuna , P. Visweswara Rao , Aishah Adam and K. Sathyavelu Reddy
  Recent studies are emphasizing on cure and or prevent the diabetes-associated complications by using herbal medicines, since complications are increasing around the world. The present study was aimed to investigate the pharmacological efficacies of Pimpinella tirupatiensis (Pt) extracts against diabetes-associated altered urea cycle and liver function markers. In this study, diabetes was induced by streptozotocin (STZ) injection (40 mg kg-1 b.wt.) in rats, and treated with P. tirupatiensis extracts for 30 days (750 mg kg-1 b.wt. orally). The significant (p<0.01) decrease in body weights, elevated serum glucose, urea, uric acid and creatinine levels along with elevated Aspartate amino transferase (AST) and Alanine amino transferase (ALT) activities were observed in diabetic rats. Interestingly, diabetic rats treated with P. tirupatiensis aqueous extracts showed significantly (p<0.01) lowered serum glucose levels and regained body weights compared to untreated diabetic rats. Elevated urea and uric acid contents were also significantly (p<0.01) controlled by P. tirupatiensis, which were similar to the standard anti-diabetic drug glibenclamide treatment. Furthermore, increased both AST and ALT activities were attenuated by P. tirupatiensis, which indicates diabetes-induced adverse effects on liver function markers were alleviated. These results clearly demonstrating that increased hostile milieu in urea cycle and liver function markers under diabetic condition could be reversed by P. tirupatiensis treatment. This study suggests that P. tirupatiensis aqueous extracts may be used as anti-diabetic remedy, however further confirmatory studies are necessary.
  P. Visweswara Rao , P. Sujana , T. Vijaykanth , Nanda Siva Sankar , B. Vijaya Kumar , Dhananjaya Naidu and S.H. Gan
  Hemidesmus indicus (H. indicus), Ocimum sanctum (O. sanctum) and Tinospora cordifolia (T. cordifolia) are three important medicinal plants in traditional Indian medicine. In this study, the methanolic and chloroform extracts of different plant parts (roots, stems and leaves) of H. indicus, O. sanctum and T. cordifolia were subjected to phytochemical, antibacterial, antifungal and antioxidant tests. Phytochemical screening of both extracts of each plant part revealed the presence of phytochemicals such as alkaloids, flavonoids, phenolic compounds, steroids and tannins. The methanolic extracts of all three plants exhibited greater antibacterial and antioxidant effects than the chloroform extracts. These effects could be related to the high content of phytochemical constituents such as alkaloids, steroids, tannins, flavonoids and phenols. When comparing the various plant parts, the roots of H. indicus had the highest number of antimicrobial activities, showing antibacterial properties against all of the investigated organisms except for one (A. flavus). The H. indicus leaf extract had antibacterial activities against S. aureus, E. coli and K. pneumoniae while the stem was effective against P. vulgaris and A. niger. The root of T. cordifolia has the second highest antimicrobial activity, acting against five different organisms (B. subtilis, S. aureus, K. pneumoniae, P. vulgaris and A. niger). O. sanctum leaf extract exhibits antibacterial activity against B. subtilis and E. coli, while the stem is only effective against B. subtilis. The methanolic root and stem extracts of H. indicus, the methanolic leaf extract of O. sanctum and the stem extract of T. cordifolia also have antioxidant potential.
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