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Articles by P. Uma Devi
Total Records ( 4 ) for P. Uma Devi
  P. Uma Devi and P. Chinnaswamy
  The aim of the present study was to estimate the effect of age and gender on the levels of primary and secondary antioxidants and Malondialdehyde in red blood cells of the selected Schizophrenia patients. In our present study, the activities of six free radical scavenging enzymes (super oxide dismutase (SOD), catalase (CAT)), glutathione peroxidase (GSH-Px), glutathione Transferase (GST), glucose-6-phosphate dehydrogenase (G6PD), Caeruloplasmin ferroxidase (Cp) and the level of thiobarbituric acid-reactive substances (TBARS) as an index of lipid per oxidation were analyzed in the different age groups of schizophrenia patients. Role of gender was also analyzed in both schizophrenia and control subjects. It was observed from the results that there was a significant increase in erythrocyte MDA levels and activity of SOD and a significant decrease in erythrocyte CAT,GSH- Px, Cp-ferroxidase and G6PD levels in patients with schizophrenia, when compared to controls (p<0.01). The results have also shown that among different age groups, highly significant oxygen free radical production, evidenced by increased levels of MDA and decreased levels of antioxidant enzymes activity was found in adult and elderly schizophrenia patients, which supports the more pronounced oxidative stress in adult and elderly schizophrenia patients when compared to young schizophrenia patients. The statistically more significant increase (p<0.001) in the activity of SOD in elderly schizophrenia subjects may be a compensatory regulation in response to increased oxidative stress in elders. The decreased concentrations of the CAT, GSH-Px, G6PD and Cp-ferroxidase support the hypothesis that lipid per oxidation is an important causative factor in the pathogenesis of schizophrenia. These data reveal that antioxidant defense mechanisms might be impaired a lot in normal elderly people and schizophrenia patients with age group above 30 (i.e., adults and elders). As for as gender concerned, we observed a significant raise in the levels MDA, SOD and significant decrease in the levels of selected antioxidant enzymes in schizophrenia male and female subjects when compared with the respective control male and female subjects (p<0.01). But we found statistically more significant increase in the levels of MDA and highly significant decrease in the levels of the secondary antioxidant enzymes G6PD and Cp ferroxidase (p<0.001) were found in schizophrenia males when compared with schizophrenia females. Supplementation of antioxidants may prevent further oxidative injury in elderly schizophrenia patients.
  S. Subakanmani , S. Murugan and P. Uma Devi
  The purpose of the study was to investigate the anti-depressant like effect of ethanolic extract of H. hookerianum (EEHh 200 and 400 mg kg–1 p.o.,) and its glycosidic flavonoid enriched extract of ethanolic extract of H. hookerianum (GFHh 100 mg kg–1 p.o.,) in reserpine induced (2 mg kg–1 i.p.,) Swiss albino mice. The flavonoidal constiteuents in EEHh and GFHh was confirmed by HPLC. The behavioral analysis of forced swimming test, tail suspension test, locomotor activity in mice has been conducted. Brain superoxide dismutase, catalase, glutathione and lipid peroxidation were estimated biochemically. Brain monoamine oxidase (A and B) activity has been carried out by double beam spectrophotometer. All the values in this study indicated that the GFHh posses well specified antidepressant activity than EEHh due to higher concentration of flavonoids as confirmed by HPLC.
  P. Uma Devi , D. Devipriya , S. Murugan , S. Selvi , S. Suja and P Chinnaswamy
  This study aims to measure Total Antioxidant Capacity (TAC) and Total Peroxides (TP) in schizophrenia patients with positive, negative and cognitive symptoms using Ferric Reducing Activity of Plasma (FRAP) and evaluate its relations with oxidative stress. We measured the plasma total antioxidant potential and total peroxides in 60 schizophrenia patients and in 60 well-matched non-schizophrenic control subjects. The association between the total antioxidative-oxidative potential and the symptoms, severity of schizophrenia were studied. Total antioxidant capacity/total peroxide of the clinical samples was measured using latest spectrophotometric measurement method. Results showed that plasma TAC was found to be lower in patients with schizophrenia than those of controls. On the contrary, the patients had high total plasma peroxide levels. Oxidative Stress Index (OSI) values of the patients were significantly higher than those of controls (p<0.001). Plasma TAC of each schizophrenia symptoms were significantly lower than healthy controls (p<0.01 for patients with negative and cognitive symptoms and p<0.001 for patients with positive symptoms). When intragroup comparisons were performed, patients with positive symptoms had significantly very low plasma TAC levels (p<0.001) compared to other negative (p<0.01) and cognitive subtypes (p<0.01). Plasma TAC in schizophrenia patients was significantly and inversely correlated with symptom severity. This study indicates that schizophrenia is associated with increased oxidative stress, depleted antioxidant status in schizophrenia subjects and supplementation with more antioxidative supplements could be considered in treatment.
  S. Subakanmani , S. Murugan and P. Uma Devi
  Gold has been used as antidepressants in Indian traditional medicine. Hypericum species are used as alternative to conventional medicines for the treatment of neurodegenerative diseases. The present study focuses on synthesis and characterization of gold nanoparticles (AuNPs) using Hypericum hookerianum and its antiparkinson like effect in haloperidol (1 mg kg–1; ip) induced swiss albino mice. The synthesized AuNPs were characterized by ultraviolet-visible spectroscopy, scanning electron microscopy; energy dispersive X-ray spectrum and fourier transform infrared spectroscopy. The parkinson induced mice were treated with ethanolic extract of H. hookerianum (EEHH) (400 mg kg–1) and H. hookerianum synthesized gold nanoparticles (HHGNps) (40 mg kg–1). Behavioral analyses of mice were examined by rota rod test, gait analysis, wire hang test and their neurobiochemical analysis (dopamine and glutamate) by spectrofluorimetry. In this study, the haloperidol induced group showed depleted dopamine and increased glutamate levels, whereas treated groups exhibited significantly restored values. Among the extracts, EEHH showed well pronounced antiparkinson like effect due to its neuroprotective flavonoids and surprisingly HHGNps treated groups showed greater antiparkinson like effect. The green synthesis of AuNPs showed promising effects for the modern therapeutic era especially with regard to parkinson’s disease.
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