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Articles by P. Silambu Janaki
Total Records ( 1 ) for P. Silambu Janaki
  R. Paramaguru , P. Silambu Janaki , M. Bavani Eswaran , Ch.V. Rao , A.K.S. Rawat and M. Vijayakumar
  Background: The high antioxidant activity compounds derived from plants are paramount demand for the pharmaceutical, food industries, mitigating their use as replacements for synthetic antioxidants which are playing significant role in preventing many diseases. This research study was designed to investigate the free radical scavenging and lipid peroxidation inhibition potential of 50% ethanolic extract of leaves of Murraya paniculata (MPET) and its various fractions of hexane (MPHF), chloroform (MPCF), ethyl acetate (MPEF) and methanol (MPMF). Materials and Methods: The free radical-scavenging potential of all fractions of Murraya paniculata extract were determined by β-carotene bleaching assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, Nitric oxide (NO), Hydroxyl radical (OH) and ferryl bipyridyl complex scavenging activity. Similarly, Lipid Peroxidation inhibition (LPO) using Thiobarbituric Acid Reactive Substances (TBARS) in rat liver homogenate and total antioxidant capacity. In addition to that integral anti oxidative capacity was studied by Photochemiluminescence assay (PCL). Results: In β-carotene bleaching assay, MPEF showed acme percentage of antioxidant activity, MPET showed moderate percentage of antioxidant activity, good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH and the same showed modest scavenging activity against NO, OH, ferryl bipyridal complex and LPO inhibition. Further among the fractions, MPEF showed potent scavenging activity against DPPH, NO, OH, ferryl bipyridal complex and LPO Inhibition. MPMF showed moderate scavenging activity against DPPH, OH, NO Radicals. Conclusion: The 50% ethanolic extract of leaves of Murraya paniculata and its ethyl acetate fraction (MPEF) were very effective antioxidants.
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