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Articles by P Ferrari
Total Records ( 2 ) for P Ferrari
  P Ferrari , J Xiao , A Ukich and A. Irish

Aim. The aim of this study was to analyse the association between chronic kidney disease (CKD) defined by an estimated glomerular filtration rate (eGFR) <60 ml/min/ 1.73 m2 and anaemia in older people.

Background. Guidelines focus on early identification and management of CKD to prevent CKD progression and cardiovascular disease. However, the significance of CKD classification using eGFR in older people is unclear.

Methods. Serum creatinine and haemoglobin from individuals attending non-nephrology outpatient clinics were extracted from the state pathology provider over a 4-month period. The associations between eGFR, gender, age and haemoglobin were explored.

Results. Serum creatinine in 9853 individual patients aged ≥15 years was available for analysis. Haemoglobin was simultaneously available in 8752 (88.8%) subjects. There was a negative relationship between age and median eGFR, and the slope of the regression line was –0.68 ml/min/year for males and –0.74 ml/min/year for females. Over 35% of individuals ≥65 years were classified as having CKD stage ≥3. Odds ratios for haemoglobin <100 g/l for an eGFR <15, 15–29 and 30–59 versus reference GFR ≥60 ml/ min/1.73 m2 in subjects 25–44 years were 34.2 (30.7–37.7), 23.4 (20.2–26.6) and 7.2 (5.3–9.1), respectively. In comparison, these were 8.9 (6.7–11.1), 5.6 (4.9–7.3) and 1.6 (1.1–2.1), respectively, in subjects ≥65 years. In subjects ≥65 years, odds ratios for haemoglobin <100 g/l for an eGFR 30–44 and 45–59 ml/min/1.73 m2 versus reference GFR ≥60 ml/min/1.73 m2 were 1.9 (1.3–2.5) and 1.2 (0.7–1.7), respectively.

Conclusions. An eGFR <60 ml/min/1.73 m2 is very common in older people. Only an eGFR <45 ml/min/1.73 m2 identified a smaller sub-group of older people with an increased prevalence of significant anaemia suggesting a clinically relevant disease. The benefits of identifying older people with an eGFR ≥45 ml/min/1.73 m2 need to be determined.

  P Ferrari , G Venturi , G Gualdrini , P. L Rossi , M Mariselli and R. Zannoli

Interventional radiology, among guided X-rays procedures, is a methodology characterised by high level of doses, both for the patient and for the medical staff. The aim of the present study is to estimate the dose associated with coronary angiography procedures by means of numerical models (simplified and anthropomorphic) and MCNPX Monte Carlo code. Numerical estimates were supported by measurement performed with a dose area product meter that is commonly employed in such kind of studies. In the present work the main considerations and the preliminary results are presented.

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