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Articles by P Colletti
Total Records ( 2 ) for P Colletti
  Y Yang , A Raine , K. L Narr , P Colletti and A. W. Toga
 

Context  Despite the repeated findings of impaired fear conditioning and affective recognition in psychopathic individuals, there has been a paucity of brain imaging research on the amygdala and no evidence suggesting which regions within the amygdala may be structurally compromised in individuals with psychopathy.

Objective  To detect global and regional anatomical abnormalities in the amygdala in individuals with psychopathy.

Design  Cross-sectional design using structural magnetic resonance imaging.

Setting  Participants were recruited from high-risk communities (temporary employment agencies) in the Los Angeles, California, area and underwent imaging at a hospital research facility at the University of Southern California.

Participants  Twenty-seven psychopathic individuals as defined by the Hare Psychopathy Checklist–Revised and 32 normal controls matched on age, sex, and ethnicity.

Main Outcome Measures  Amygdala volumes were examined using traditional volumetric analyses and surface-based mesh modeling methods were used to localize regional surface deformations.

Results  Individuals with psychopathy showed significant bilateral volume reductions in the amygdala compared with controls (left, 17.1%; right, 18.9%). Surface deformations were localized in regions in the approximate vicinity of the basolateral, lateral, cortical, and central nuclei of the amygdala. Significant correlations were found between reduced amygdala volumes and increased total and facet psychopathy scores, with correlations strongest for the affective and interpersonal facets of psychopathy.

Conclusions  Results provide the first evidence, to our knowledge, of focal amygdala abnormalities in psychopathic individuals and corroborate findings from previous lesion studies. Findings support prior hypotheses of amygdala deficits in individuals with psychopathy and indicate that amygdala abnormalities contribute to emotional and behavioral symptoms of psychopathy.

  F. R Sattler , C Castaneda Sceppa , E. F Binder , E. T Schroeder , Y Wang , S Bhasin , M Kawakubo , Y Stewart , K. E Yarasheski , J Ulloor , P Colletti , R Roubenoff and S. P. Azen
 

Context: Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat.

Objectives: We tested the hypothesis that physiological supplementation with testosterone and GH together improves body composition and muscle performance in older men.

Design, Setting, and Participants: One hundred twenty-two community-dwelling men 70.8 ± 4.2 yr of age with body mass index of 27.4 ± 3.4 kg/m2, testosterone of 550 ng/dl or less, and IGF-I in lower adult tertile (≤167 ng/dl) were randomized to receive transdermal testosterone (5 or 10 g/d) during a Leydig cell clamp plus GH (0, 3, or 5 µg/kg · d) for 16 wk.

Main Outcome Measures: Body composition by dual-energy x-ray absorptiometry, muscle performance, and safety tests were conducted.

Results: Total lean body mass increased (1.0 ± 1.7 to 3.0 ± 2.2 kg) as did appendicular lean tissue (0.4 ± 1.4 to 1.5 ± 1.3 kg), whereas total fat mass decreased by 0.4 ± 0.9 to 2.3 ± 1.7 kg as did trunk fat (0.5 ± 0.9 to 1.5 ± 1.0 kg) across the six treatment groups and by dose levels for each parameter (P ≤ 0.0004 for linear trend). Composite maximum voluntary strength of upper and lower body muscles increased by 14 ± 34 to 35 ± 31% (P < 0.003 in the three highest dose groups) that correlated with changes in appendicular lean mass. Aerobic endurance increased in all six groups (average 96 ± 137sec longer). Systolic and diastolic blood pressure increased similarly in each group with mean increases of 12 ± 14 and 8 ± 8 mm Hg, respectively. Other predictable adverse events were modest and reversible.

Conclusions: Supplemental testosterone produced significant gains in total and appendicular lean mass, muscle strength, and aerobic endurance with significant reductions in whole-body and trunk fat. Outcomes appeared to be further enhanced with GH supplementation.

 
 
 
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