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Articles by Osama Mesilhy Saleh
Total Records ( 1 ) for Osama Mesilhy Saleh
  Mohamed Mohamed Soliman , Hossam Fouad Attia , Samir Ahmed El-Shazly and Osama Mesilhy Saleh
  Cinnamon Extracts (CE) are widely used in Middle East and Asian countries as herbal medication for diabetes. It contains biologically active substances which have in vivo hypoglycemic activity and probably improve insulin sensitivity. Up till now the molecular mechanism of CE on genes expression is not yet determined. In this study, we examined the effect of CE (200 mg kg-1 body weight) in obesity and diabetic Wistar rats by testing its effect on genes related to lipids and glucose metabolism. Firstly, to test anti-obesity actions of CE, rats were fed High Fat Diet (HFD) for 3 months then treated with CE for 2 months. Secondly, experimentally diabetic rats were treated with CE for 2 months to examine its antidiabetic action. The results showed that CE treatment did not show any significant changes in plasma levels of obesity related parameters including lipid profiles, leptin and lipase enzyme. However, liver histology showed decrease in lipid and glycogen accumulation in CE treated rats. Moreover, CE induced significant (p<0.05) decrease in haptoglobin levels. In diabetic experiments, CE treatment normalized significantly (p<0.05) the increase in lipid profiles and glucose levels occurred in diabetic rats. In parallel, CE lowered glucose levels through the increase in insulin secretion from still working β cells. The antidiabetic action of CE was confirmed as CE treated diabetic rats showed an increase in mRNA expression of leptin, PPAR-gamma and adiponectin. In conclusion, CE is not anti-obesity herb but has antidiabetic and insulin-mimetic actions through the regulation of genes related to lipid and glucose metabolism.
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