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Articles by Onyechi O. Obidoa
Total Records ( 2 ) for Onyechi O. Obidoa
  Anthony C.C. Egbuonu , Ifeoma I. Ijeh , Onyinye N.C. Egbuonu , Lawrence U.S. Ezeanyika and Onyechi O. Obidoa
  A reduction in the concentration of nitric oxide, a biosynthetic product of L-arginine (ARG) was associated with the pathophysiology of Metabolic Syndrome (MES). This study assessed the effect of ARG on some anthropometric parameters of MES in normal rats. Female wistar rats (60-80 g) were randomized into two groups (n = 8 animals) and exposed to 60 mg kg-1 (b.wt.) of ARG and 3 mL kg-1 b.wt. of distilled water respectively as treated and control groups. Twenty eight days oral exposure to ARG caused a significant (p<0.01) increase in feed efficiency (4.83±0.06 or 19.26 %) and total water consumption (0.83±0.17 L or 25.75%), but a significant (p<0.01) decrease in total feed intake (0.31±0.06 kg or 20.51%), indicating suppressed calorie storage or decreased energy balance that may improve MES. Changes observed in the rats final length (0.30±0.01 m or 3.45%), total body weight gain (0.05±0.01 kg or 16.66%), body mass index (1.24±0.15 kg m-2 or 1.59%) and lean body weight (0.27±0.03 kg or 0.73%) though insightful, were not significant (p>0.05), warranting follow up. From the results of Pearson correlations analysis, feed efficiency correlated negatively with total feed intake (p = 0.01) but positively (p = 0.05) with total water consumption, suggesting apparent synergy in the ARG-induced effects. Thus, ARG significantly improved some anthropometric parameters of MES, hence may improve some MES features related to excessive calorie build up or storage in the female rats. The findings warrant similar studies on a longer duration for meticulousness.
  Anthony C.C. Egbuonu , Ifeoma I. Ijeh , Lawrence U.S. Ezeanyika and Onyechi O. Obidoa
  High blood pressure (a condition associated with vascular constriction) is a major feature of metabolic syndrome (MES). MES, a constellation of metabolic disorders, is prevalently higher in females and was associated with a reduced concentration of a vasodilator molecule, Nitric Oxide (NO). L-arginine (ARG), a precursor of NO may improve MES, warranting this study. Two groups (n = 8) of female Wistar albino rats were (per orally for twenty eight days) exposed to a single dose of 60 mg kg-1 b.wt. of ARG and 3 mL kg-1 b.wt. of distilled water, DW, respectively as treated and control groups. Significant differences in means were separated by student’s t-test (p<0.05; p<0.01) and results expressed as Mean±Standard deviation. ARG exposure caused a significant reduction (p<0.01) in sodium ion (Na+) concentration (136.42±1.66 mmol L-1; 6.54%), but a non-significant decrease (p>0.05) in potassium ion (K+) concentration (4.54±0.66 mmol L-1; 14.01%) in the rats’ serum, suggesting improved/reduced blood pressure. ARG treatment in the rats had a significant increase (p<0.01) in Alkaline Phosphatase (ALP) activity (8.30±0.23 IU L-1; 196.43%) in the rats’ serum, indicating adverse influence on high metabolic organs, including the brain. Sodium ion had a significant negative correlation (r = 0.01) with potassium ion, whereas the heart histomorphology revealed degenerations in the ARG-fed rats, apparently confirming the observations and suggestions thereto. Thus, ARG may improve blood pressure in the rats, perhaps at the expense of compromised heart function and histology of the rats. These may be pointing to a new arginine phenomenon, hence warrant follow up.
 
 
 
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