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Articles by Omer OZCAN
Total Records ( 2 ) for Omer OZCAN
  Osman Metin IPCIOGLU , Omer OZCAN , Mustafa GULTEPE , Hakan TEKELI and Mehmet Guney SENOL

Aims: Although vitamin B12 is currently used as a treatment option in patients with migraine, a possible cobalamin deficiency in those patients has not yet been investigated. In this study, we aimed to investigate cobalamin metabolism in patients with migraine.
Materials and Methods: Fifty women having migraine without aura were matched with healthy controls (n=6) with the same age distribution. Fasting serum vitamin B12, folate, plasma total homocysteine (tHcy) and first morning urine methylmalonic acid (MMA) levels were determined in patient and control groups. Statistical differences in laboratory parameters between patient and control groups were analyzed by SPSS for Windows software.
Results: Vitamin B12 and folate levels in the patient group were not different from those of the control group. Although mean plasma tHcy and urine MMA levels in the patient group were significantly higher than those in the control group, only a small portion (12%) of patients had plasma tHcy levels higher than the reference range, whereas 70% of patients had increased urine MMA levels.
Conclusions: There was a functional vitamin B12 deficiency represented by elevated urine MMA levels in patients having migraine without aura. We suggest that vitamin B12 treatment for migraine patients should be started thereafter screening for MMA elevations.

  Halil YAMAN , Tuncer CAYCI , Melik SEYREK , Emin Ozgur AKGUL , Yasemin GULCAN KURT , Ibrahim AYDIN , Hakan YAREN , Erdinc CAKIR , Omer OZCAN , Behzat CIMEN , Nurten TURKOZKAN and Mehmet Kemal ERBIL
  Aim:Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O2.-). O2.- can react with NO to produce the powerful oxidant peroxynitrite (ONOO-). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO- production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia. Materials and methods: A total of 75 animals were randomly divided into 5 groups (n = 15 animals for each group). 3-NT levels in the heart tissue were determined by high pressure liquid chromatography with a diode array detector. Results: In the group given LPS, 3-NT levels were significantly increased compared with the control, vitamin A + LPS-treated, vitamin C + LPS-treated, and melatonin + LPS-treated groups. In the vitamin A + LPS-treated group, vitamin C + LPS-treated group, and melatonin + LPS-treated group, 3-NT levels were similar to those of the control group. Conclusion: Vitamin A, vitamin C, and melatonin pretreatment significantly prevented 3-NT formation. These agents may offer an advantage in that they could improve the hemodynamics as well as reduce the formation of ONOO-.
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