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Articles by Omer BAYRAK
Total Records ( 3 ) for Omer BAYRAK

Aim: To compare the semen parameters between pregnant and nonpregnant couples with male factor infertility during intrauterine insemination (IUI).

Materials and Methods: The study included a total of 156 IUI cycles performed in our center from January 2005 to December 2006 with the indication of male infertility. IUI cycles were divided into 2 groups: group 1 pregnancy (24 cycles) and group 2 (132 cycles) nonpregnancy cycles.

Results: In both groups, progressive motility of neither initial nor processed sperm specimens was significantly different (P > 0.05). When comparisons of semen parameters in groups were performed in the initial specimen, sperm concentration and total motile sperm count (TMC) were significantly different between the groups (P = 0.03, P = 0.04, respectively). After processing specimens a definite significant difference was found in sperm concentration and inseminated motile sperm count (IMC) between pregnancy and nonpregnancy cycles (P = 0.03, P = 0.03, respectively). Although TMC > 10 × 106 provided a pregnancy rate (PR) of 18% compared with TMC < 10 × 106 (PR: 10%), no significant differences were detected (P > 0.05).

Conclusions: In addition to the initial TMC and IMC, sperm concentration in both initial and processed specimens may influence IUI-related pregnancy in male factor infertility.

  Nilgun TURHAN , Aslıhan PEKEL , Yuksel ONARAN , Zehra Candan ILTEMIR DUVAN and Omer BAYRAK
  Aim: To compare the motility yields of single or double wash after density gradient centrifugation of the ejaculate and their effects on pregnancy rates in clomiphene citrate induced intrauterine insemination (IUI) cycles. Materials and methods: This prospective randomized controlled study included 341 IUI cycles. Sperm specimens processed by density gradient centrifugation either with single wash (the single wash group, n = 170) or double wash treatment (the double wash group, n = 171). Sperm parameters before and after the preparation and the cycle outcomes were evaluated. The main outcome measure was the pregnancy rate. Results: The prewash sperm concentrations, the total motile sperm count, sperm motility and the mean percentage of normal sperm morphology of the groups were similar (P > 0.05). Post-wash sperm concentrations and inseminated motile sperm concentrations were similar in both groups (P > 0.05). Post-wash fast progressive motility (+4 motility) was significantly higher in the double wash group compared to the single wash group (P = 0.017). A total of 62 (18%) clinic pregnancies were obtained in 341 treatment cycles. Clinical pregnancy rate per insemination cycle was 11.8% for the single wash group and 24.6% for the double wash group (P = 0.003). Conclusion: Double wash treatment after density gradient centrifugation of the ejaculate yields a better post-wash fast progressive sperm motility and higher IUI pregnancy rate after ovarian stimulation with clomiphene citrate.
  Nilgun TURHAN , Aslihan PEKEL , Aylin AYRIM and Omer BAYRAK
  Aim: To investigate the association between prewash progressive sperm motility and pregnancy rate in cases of severely oligoasthenozoospermic patients in intracytoplasmic sperm injection (ICSI) cycles. Materials and methods: The study included 80 infertile couples who were treated by ICSI due to severe oligoasthenozoospermia (<106). Results were obtained by retrospective analysis of data that are regularly entered into SPSS in our In Vitro Fertilization Unit. Female patients older than 35 years were excluded. The patients were divided into 2 groups according to prewash progressive sperm motility. Group I had progressive sperm motility below 10% (n = 40), and group II had progressive sperm motility equal to or greater than 10% (n = 40). The main outcome measure was the clinical pregnancy rate. Results: The patient characteristics were similar in both groups. There were no significant differences between the 2 groups in terms of total number of oocytes retrieved, number of mature oocytes, fertilization rate, or the number of transferred embryos. A total of 38 (47.5%) clinical pregnancies were obtained in 80 ICSI treatment cycles. The clinical pregnancy rate was significantly higher in group II (62.5% [25/40] than in group I (32.5% [13/40]), with P = 0.014. Conclusion: Severe sperm motility impairment results in human infertility, which can be overcome by ICSI. The data from this study demonstrated that severe progressive motility defects in cases of severe oligoasthenozoospermia do not prevent fertilization or normal embryo production in ICSI cycles; however, the rate of ICSI success may be influenced by progressive sperm motility. Our results show that oligoasthenozoospermic patients with progressive sperm motility above 10% have better clinical pregnancy results.
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