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Articles by Oluwafeyikemi O. Adekola
Total Records ( 1 ) for Oluwafeyikemi O. Adekola
  Olufunmiso Olusola Olajuyigbe and Oluwafeyikemi O. Adekola
  Background: Several in vivo studies indicated that interactions between antacids and some therapeutic agents could result in treatment failures. Most of these studies have failed to take cognizance of the in vitro effects of these interactions on infectious agents. Hence, this study investigated the interactions between erythromycin and polyvalent metallic ions and the effects of combining them against some clinical bacterial isolates in vitro. Methods: Different concentrations of erythromycin ranging between 2.5 and 30.0 μg mL-1 and their combination with different concentrations, 0.05-1.0 mg mL-1, of polyvalent metallic ions were tested against some clinical bacterial isolates. After the incubation period, inhibition zones from erythromycin alone and its combination with polyvalent metallic ions were measured and subjected to statistical analysis. Result: There was antagonistic interaction between erythromycin and the polyvalent metallic ions resulting in a significant reduction in the antibacterial activity of erythromycin on the clinical isolates. The possibility of bacterial resistant development as a result of combining these two drugs was observed while treatment failure was suggested by the associated reduction of the inhibition zones. Conclusion: In conclusion, combining erythromycin and polyvalent metallic ions should be discouraged in chemotherapy since the observed antagonistic interaction could result in development of bacterial resistance or treatment failure.
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